Caffeic and chlorogenic acids in Ilex paraguariensis extracts are the main inhibitors of AGE generation by methylglyoxal in model proteins

被引：156

作者：

Gugliucci, A. ^{[1
]}

Markowicz Bastos, Deborah H. ^{[2
]}

Schulze, John ^{[1
]}

Ferreira Souza, Marina F. ^{[2
]}

机构：

[1] Touro Univ Calif, Div Basic Med Sci, Glycat Oxidat & Dis Lab, Vallejo, CA 94592 USA

[2] Univ Sao Paulo, Dept Nutr, Sch Publ Hlth, BR-01246904 Sao Paulo, Brazil

来源：

FITOTERAPIA | 2009年 / 80卷 / 06期

基金：

巴西圣保罗研究基金会;

关键词：

Phenolic acids; Saponin; Glycation; Nutraceutical; Ilex paraguariensis; URSOLIC ACID; RAT HEPATOCYTES; LIVER-DAMAGE; GREEN TEA; IN-VITRO; GLYCOSYLATION; GLYCOXIDATION; ANTIOXIDANT; SAPONINS; CELLS;

D O I：

10.1016/j.fitote.2009.04.007

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The present study concentrates on the evaluation of the anti-glycation effect of some bioactive substances present in yerba mate (Ilex paraguariensis): 5-caffeoylquinic acid, caffeic acid and a sapogenin (oleanolic acid). Bovine serum albumin and histones were incubated in the presence of methylglyoxal with or without the addition of 5-caffeoylquinic acid, caffeic acid and oleanolic acid. After the incubation period, advanced glycation end product (AGE) fluorescence spectra were performed and protein structural changes were evaluated by Sodium Dodecyl Sulfate Polyacrylamide Gel Electrophoresis. Chlorogenic acid, caffeic acid are the main substances responsible for the anti-glycation effect of mate tea. (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：339 / 344

页数：6

共 33 条

[1] Peptide mapping identifies hotspot site of modification in human serum albumin by methylglyoxal involved in ligand binding and esterase activity [J].