cHCC-CCA: Consensus terminology for primary liver carcinomas with both hepatocytic and cholangiocytic differentation

被引：263

作者：

Brunt, Elizabeth ^{[1
]}

Aishima, Shinichi ^{[2
]}

Clavien, Pierre-Alain ^{[3
]}

Fowler, Kathryn ^{[4
]}

Goodman, Zachary ^{[5
]}

Gores, Gregory ^{[6
]}

Gouw, Annette ^{[7
]}

Kagen, Alex ^{[8
]}

Klimstra, David ^{[9
]}

Komuta, Mina ^{[10
]}

Kondo, Fukuo ^{[11
]}

Miksad, Rebecca ^{[12
]}

Nakano, Masayuki ^{[13
]}

Nakanuma, Yasuni ^{[14
]}

Ng, Irene ^{[15
,16
]}

Paradis, Valerie ^{[17
]}

Park, Young Nyun ^{[18
]}

Quaglia, Alberto ^{[19
]}

Roncalli, Massimo ^{[20
]}

Roskams, Tania ^{[21
]}

Sakamoto, Michiie ^{[22
]}

Saxena, Romil ^{[23
]}

Sempoux, Christine ^{[24
]}

Sirlin, Claude ^{[25
]}

Stueck, Ashley ^{[26
]}

Thung, Swan ^{[27
]}

Tsui, W. M. S. ^{[28
]}

Wang, Xin-Wei ^{[29
]}

Wee, Aileen ^{[30
]}

Yano, Hirohisa ^{[31
]}

Yeh, Matthew ^{[32
]}

Zen, Yoh ^{[33
]}

Zucman-Rossi, Jessica ^{[34
]}

Theise, Neil ^{[35
]}

机构：

[1] Washington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO 63130 USA

[2] Saga Univ, Dept Pathol & Microbiol, Saga, Japan

[3] Univ Hosp Zurich, Surg, Zurich, Switzerland

[4] Washington Univ, Sch Med, Dept Radiol, St Louis, MO 63130 USA

[5] Inova Hlth Syst, Pathol, Falls Church, VA USA

[6] Mayo Clin, Dept Med, Div Gastroenterol & Hepatol, Rochester, MN USA

[7] Univ Med Ctr Groningen, Pathol & Med Biol, Groningen, Netherlands

[8] Mt Sinai Roosevelt, Radiol, New York, NY USA

[9] Mem Sloan Kettering Canc Ctr, Pathol, 1275 York Ave, New York, NY 10021 USA

[10] Catholic Univ Louvain, Serv Anatomopathol, Louvain La Neuve, Belgium

[11] Teikyo Univ, Dept Pathol, Sch Med, Tokyo, Japan

[12] Beth Israel Deaconess, Oncol, Boston, MA USA

[13] Shonan Fujisawa Tokushuukai Hosp, Pathol, Fujisawa, Kanagawa, Japan

[14] Fukui Ken Saiseikai Byoin, Pathol, Fukui, Japan

[15] Univ Hong Kong, LKS Fac Med, Hong Kong, Hong Kong, Peoples R China

[16] Univ Hong Kong, State Key Lab Liver Res, Hong Kong, Hong Kong, Peoples R China

[17] Univ Paris Diderot, Hop Beaujon, INSERM, Pathol,UMR, Clichy, France

[18] Yonsei Univ, Pathol, Seoul, South Korea

[19] Kings Coll Hosp London, Inst Liver Studies, London, England

[20] Humanitas Hosp, Pathol, Rome, Italy

[21] Univ Leuven, Dept Radiol & Pathol, Lab & Translat Tissue Res, Leuven, Belgium

[22] Keio Univ, Sch Med, Dept Pathol, Tokyo, Japan

[23] Indiana Univ Sch Med, Pathol & Lab Med & Med, Indianapolis, IN 46202 USA

[24] Lausanne Univ Hosp, Inst Pathol, Pathol, Lausanne, Switzerland

[25] Univ Calif San Diego, Liver Imaging Grp, La Jolla, CA 92093 USA

[26] Dalhousie Univ, Dept Pathol, Halifax, NS, Canada

[27] Icahn Sch Med Mt Sinai, Pathol, New York, NY 10029 USA

[28] Caritas Med Ctr, Pathol, Hong Kong, Hong Kong, Peoples R China

[29] NCI, Lab Human, Carcinogenesis, Sect Liver Carcinogenesis, Bethesda, MD 20892 USA

[30] Natl Univ Singapore, Yong Loo Lin Sch Med, Pathol, Singapore, Singapore

[31] Kurume Univ, Sch Med, Pathol, Kurume, Fukuoka, Japan

[32] Univ Washington, Pathol, Med, Seattle, WA 98195 USA

[33] Kobe Univ, Grad Sch Med, Diagnost Pathol, Kobe, Hyogo, Japan

[34] Univ ParisDescartes, UMR 1162, Equipe Labellisee Ligue Canc,,Sorbonne Paris Cite, Inst Univ Hematol,Labex Immunooncol,Fac Med, Paris, France

[35] NYU, Sch Med, Pathol, New York, NY 10003 USA

来源：

HEPATOLOGY | 2018年 / 68卷 / 01期

关键词：

COMBINED HEPATOCELLULAR-CHOLANGIOCARCINOMA; STEM-CELL FEATURES; CHOLANGIOLOCELLULAR CARCINOMA; CYTOKERATIN-19; EXPRESSION; COMPUTED-TOMOGRAPHY; IMAGING FEATURES; ENHANCED CT; KERATIN; 19; PATTERNS; SUBTYPES;

D O I：

10.1002/hep.29789

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Primary liver carcinomas with both hepatocytic and cholangiocytic differentiation have been referred to as combined (or mixed) hepatocellular-cholangiocarcinoma. These tumors, although described over 100 years ago, have attracted greater attention recently because of interest in possible stem cell origin and perhaps because of greater frequency and clinical recognition. Currently, because of a lack of common terminology in the literature, effective treatment and predictable outcome data have been challenging to accrue. This article represents a consensus document from an international community of pathologists, radiologists, and clinicians who have studied and reported on these tumors and recommends a working terminology for diagnostic and research approaches for further study and evaluation. Conclusion: It is recommended that diagnosis is based on routine histopathology with hematoxylin and eosin (H & immunostains are supportive, but not essential for diagnosis. (Hepatology 2018;68:113-126).

引用

页码：113 / 126

页数：14

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