Pregabalin does not affect fracture healing adversely

被引：5

作者：

Kockara, Nizamettin ^{[1
]}

Sofu, Hakan ^{[1
]}

Issin, Ahmet ^{[1
]}

Cetinkaya, Mehmet ^{[2
]}

Tayfur, Mahir ^{[3
]}

Suleyman, Bahadir ^{[4
]}

机构：

[1] Erzincan Univ, Dept Orthoped & Traumatol, Fac Med, TR-24100 Erzincan, Turkey

[2] Mengucekgazi Training & Res Hosp, Dept Orthoped & Traumatol, Erzincan, Turkey

[3] Erzincan Univ, Dept Pathol, Fac Med, Erzincan, Turkey

[4] Erzincan Univ, Fac Med, Dept Pharmacol, Erzincan, Turkey

来源：

EKLEM HASTALIKLARI VE CERRAHISI-JOINT DISEASES AND RELATED SURGERY | 2017年 / 28卷 / 01期

关键词：

Fracture healing; pharmaceutical preparations; pregabalin; rat model; RATS; PAIN;

D O I：

10.5606/ehc.2017.50897

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

Objectives: This study aims to assess the radiographic, histological, and biomechanical effects of pregabalin on fracture healing in a rat model of femur fracture. Materials and methods: A total of 32 female WistarAlbino rats (mean age 12 +/- 1 weeks; mean body weight 236 +/- 12 grams) were randomized into four groups with eight rats in each group. Groups A and B were the control groups whereas C and D were the treatment groups. Drugs were delivered by oral gavage. Radiographic, histological and biomechanical evaluations were performed after sacrificing the rats in groups A and C on 15(th) postoperative day and the rats in groups B and D on 30(th) postoperative day. Results: Although radiographic results were better in groups A and B than groups C and D at the end of 15(th) day, no significant difference was detected at the end of 30(th) day. No statistically significant differences were observed between the groups on 15(th) a nd 30(th) days in terms of histological or biomechanical evaluation. Conclusion: Administration of pregabalin did not affect fracture healing process adversely in rats.

引用

页码：19 / 24

页数：6

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