Ultra-sensitive fluorescent probes for hypochlorite acid detection and exogenous/endogenous imaging of living cells

被引：54

作者：

Jiang, Yin ^{[1
,2
]}

Zheng, Guansheng ^{[1
]}

Duan, Qinya ^{[1
]}

Yang, Liu ^{[3
]}

Zhang, Jie ^{[3
]}

Zhang, Huatang ^{[1
]}

He, Jun ^{[1
]}

Sun, Hongyan ^{[3
]}

Ho, Derek ^{[2
]}

机构：

[1] Guangdong Univ Technol, Sch Chem Engn & Light Ind, Guangzhou 510006, Guangdong, Peoples R China

[2] City Univ Hong Kong, Dept Mat Sci & Engn, 83 Tat Chee Ave, Kowloon, Hong Kong, Peoples R China

[3] City Univ Hong Kong, Dept Chem, 83 Tat Chee Ave, Kowloon, Hong Kong, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2018年 / 54卷 / 57期

基金：

中国博士后科学基金; 中国国家自然科学基金;

关键词：

IN-VIVO; OXIDATIVE STRESS; RECENT PROGRESS; LIVE-CELL; MITOCHONDRIA; CANCER; HOCL; MYELOPEROXIDASE; GLYCOPROBES; MECHANISMS;

D O I：

10.1039/c8cc03963a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Two fluorescent probes (Naph-1 and Naph-2), which can be prepared via a facile process, have been developed to detect hypochlorite acid (HOCl). The N,N-dimethyl thiocarbamate group quenches the fluorescence of the probes through intramolecular charge transfer (ICT). Upon reaction with HOCl in aqueous buffer, Naph-1 shows ultra-high sensitivity towards HOCl through a 4600-fold increase in fluorescence intensity, as well as a detection limit of 2.37 nM. The probes have been applied to confocal fluorescence imaging of exogenous and endogenous HOCl in living cells.

引用

页码：7967 / 7970

页数：4

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