The Immunopathological and Histological Landscape of COVID-19-Mediated Lung Injury

被引：31

作者：

Zarrilli, Giovanni ^{[1
]}

Angerilli, Valentina ^{[1
]}

Businello, Gianluca ^{[1
]}

Sbaraglia, Marta ^{[1
]}

Traverso, Giulia ^{[2
]}

Fortarezza, Francesco ^{[3
]}

Rizzo, Stefania ^{[3
]}

Gaspari, Monica De ^{[3
]}

Basso, Cristina ^{[3
]}

Calabrese, Fiorella ^{[3
]}

Dei Tos, Angelo Paolo ^{[1
]}

Fassan, Matteo ^{[1
]}

机构：

[1] Univ Padua, Surg Pathol & Cytopathol Unit, Dept Med DIMED, I-35121 Padua, Italy

[2] IRCCS, IOV, Ist Oncol Veneto, I-35128 Padua, Italy

[3] Univ Padua, Dept Cardiac Thorac Vasc Sci & Publ Hlth, I-35121 Padua, Italy

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2021年 / 22卷 / 02期

关键词：

SARS-CoV-2; COVID19; pathology; cytokine storm; IL-6; AMPLIFIER; CYTOKINE STORM; FATAL COVID-19; CORONAVIRUS; INFECTIONS; RECEPTOR; AUTOPSY;

D O I：

10.3390/ijms22020974

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A complete understanding of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) physiopathology and related histopathologic lesions is necessary to improve treatment and outcome of coronavirus disease 2019 (COVID-19) patients. Many studies have focused on autopsy findings in COVID-19-related deaths to try and define any possible specific pattern. Histopathologic alterations are principally found within lungs and blood vessels, and these abnormalities also seem to have the highest clinical impact. Nevertheless, many of the morphological data collected so far are non-specific, fickle, and possibly associated with other co-existing factors. The aim of this minireview is to describe the main histopathological features related to COVID-19 and the mechanism known as "cytokine storm".

引用

页码：1 / 11

页数：11

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