Biomarkers in Paediatric Cystic Fibrosis Lung Disease

被引：17

作者：

Ramsey, Kathryn A. ^{[1
,2
]}

Schultz, Andre ^{[1
,3
,4
]}

Stick, Stephen M. ^{[1
,3
,4
]}

机构：

[1] Univ Western Australia, Telethon Kids Inst, Nedlands, WA 6009, Australia

[2] Univ N Carolina, Cyst Fibrosis Pulm Res & Treatment Ctr, Chapel Hill, NC USA

[3] Princess Margaret Hosp Children, Subiaco, WA, Australia

[4] Univ Western Australia, Sch Paediat & Child Hlth, Nedlands, WA 6009, Australia

来源：

PAEDIATRIC RESPIRATORY REVIEWS | 2015年 / 16卷 / 04期

关键词：

Paediatrics; Cystic fibrosis; Biomarkers; Pulmonary; EXHALED BREATH CONDENSATE; BRONCHOALVEOLAR LAVAGE FLUID; PSEUDOMONAS-AERUGINOSA; YOUNG-CHILDREN; PULMONARY INFLAMMATION; POTENTIAL DIFFERENCE; ADULT PATIENTS; RISK-FACTORS; INFANTS; INFECTION;

D O I：

10.1016/j.prrv.2015.05.004

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Biomarkers in cystic fibrosis are used i. for the measurement of cystic fibrosis transmembrane regulator function in order to diagnose cystic fibrosis, and ii. to assess aspects of lung disease severity (e.g. inflammation, infection). Effective biomarkers can aid disease monitoring and contribute to the development of new therapies. The tests of cystic fibrosis transmembrane regulator function each have unique strengths and weaknesses, and biomarkers of inflammation, infection and tissue destruction have the potential to enhance the management of cystic fibrosis through the early detection of disease processes. The development of biomarkers of cystic fibrosis lung disease, in particular airway inflammation and infection, is influenced by the challenges of obtaining relevant samples from infants and children for whom early detection and treatment of disease might have the greatest long term benefits. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：213 / 218

页数：6

共 96 条

[1] Sweat chloride as a biomarker of CFTR activity: Proof of concept and ivacaftor clinical trial data [J].

Accurso, Frank J. ;

Van Goor, Fredrick ;

Zha, Jiuhong ;

Stone, Anne J. ;

Dong, Qunming ;

Ordonez, Claudia L. ;

Rowe, Steven M. ;

Clancy, John Paul ;

Konstan, Michael W. ;

Hoch, Heather E. ;

Heltshe, Sonya L. ;

Ramsey, Bonnie W. ;

Campbell, Preston W. ;

Ashlock, Melissa A. .

JOURNAL OF CYSTIC FIBROSIS, 2014, 13 (02) :139-147

[2] Effect of VX-770 in Persons with Cystic Fibrosis and the G551D-CFTR Mutation [J].

Accurso, Frank J. ;

Rowe, Steven M. ;

Clancy, J. P. ;

Boyle, Michael P. ;

Dunitz, Jordan M. ;

Durie, Peter R. ;

Sagel, Scott D. ;

Hornick, Douglas B. ;

Konstan, Michael W. ;

Donaldson, Scott H. ;

Moss, Richard B. ;

Pilewski, Joseph M. ;

Rubenstein, Ronald C. ;

Uluer, Ahmet Z. ;

Aitken, Moira L. ;

Freedman, Steven D. ;

Rose, Lynn M. ;

Mayer-Hamblett, Nicole ;

Dong, Qunming ;

Zha, Jiuhong ;

Stone, Anne J. ;

Olson, Eric R. ;

Ordonez, Claudia L. ;

Campbell, Preston W. ;

Ashlock, Melissa A. ;

Ramsey, Bonnie W. .

NEW ENGLAND JOURNAL OF MEDICINE, 2010, 363 (21) :1991-2003

[3] LOWER RESPIRATORY-INFECTION AND INFLAMMATION IN INFANTS WITH NEWLY-DIAGNOSED CYSTIC-FIBROSIS [J].

ARMSTRONG, DS ;

GRIMWOOD, K ;

CARZINO, R ;

CARLIN, JB ;

OLINSKY, A ;

PHELAN, PD .

BRITISH MEDICAL JOURNAL, 1995, 310 (6994) :1571-1572

[4] THE RELATIONSHIP BETWEEN INFECTION AND INFLAMMATION IN THE EARLY STAGES OF LUNG-DISEASE FROM CYSTIC-FIBROSIS [J].

BALOUGH, K ;

MCCUBBIN, M ;

WEINBERGER, M ;

SMITS, W ;

AHRENS, R ;

FICK, R .

PEDIATRIC PULMONOLOGY, 1995, 20 (02) :63-70

[5] PROTEASE-ANTIPROTEASE IMBALANCE IN THE LUNGS OF CHILDREN WITH CYSTIC-FIBROSIS [J].

BIRRER, P ;

MCELVANEY, NG ;

RUDEBERG, A ;

SOMMER, CW ;

LIECHTIGALLATI, S ;

KRAEMER, R ;

HUBBARD, R ;

CRYSTAL, RG .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 1994, 150 (01) :207-213

[6] Induced sputum compared to bronchoalveolar lavage in young, non-expectorating cystic fibrosis children [J].

Blau, Hannah ;

Linnane, Barry ;

Carzino, Rosemary ;

Tannenbaum, Esta-Lee ;

Skoric, Billy ;

Robinson, Philip J. ;

Robertson, Cohn ;

Ranganathan, Sarath C. .

JOURNAL OF CYSTIC FIBROSIS, 2014, 13 (01) :106-110

[7] Biomarkers of neutrophilic inflammation in exhaled air of cystic fibrosis children with bacterial airway infections [J].

Bodini, A ;

D'Orazio, C ;

Peroni, D ;

Corradi, M ;

Folesani, G ;

Baraldi, E ;

Assael, BM ;

Boner, A ;

Piacentini, GL .

PEDIATRIC PULMONOLOGY, 2005, 40 (06) :494-499

[8] Developments in novel breath tests for bacterial and fungal pulmonary infection [J].

Chambers, Stephen T. ;

Scott-Thomas, Amy ;

Epton, Michael .

CURRENT OPINION IN PULMONARY MEDICINE, 2012, 18 (03) :228-232

[9] Results of a phase IIa study of VX-809, an investigational CFTR corrector compound, in subjects with cystic fibrosis homozygous for the F508del-CFTR mutation [J].

Clancy, J. P. ;

Rowe, Steven M. ;

Accurso, Frank J. ;

Aitken, Moira L. ;

Amin, Raouf S. ;

Ashlock, Melissa A. ;

Ballmann, Manfred ;

Boyle, Michael P. ;

Bronsveld, Inez ;

Campbell, Preston W. ;

De Boeck, Kris ;

Donaldson, Scott H. ;

Dorkin, Henry L. ;

Dunitz, Jordan M. ;

Durie, Peter R. ;

Jain, Manu ;

Leonard, Anissa ;

Mccoy, Karen S. ;

Moss, Richard B. ;

Pilewski, Joseph M. ;

Rosenbluth, Daniel B. ;

Rubenstein, Ronald C. ;

Schechter, Michael S. ;

Botfield, Martyn ;

Ordonez, Claudia L. ;

Spencer-Green, George T. ;

Vernillet, Laurent ;

Wisseh, Steve ;

Yen, Karl ;

Konstan, Michael W. .

THORAX, 2012, 67 (01) :12-18

[10] Multicenter Intestinal Current Measurements in Rectal Biopsies from CF and Non-CF Subjects to Monitor CFTR Function [J].

Clancy, John P. ;

Szczesniak, Rhonda D. ;

Ashlock, Melissa A. ;

Ernst, Sarah E. ;

Fan, Lijuan ;

Hornick, Douglas B. ;

Karp, Philip H. ;

Khan, Umer ;

Lymp, James ;

Ostmann, Alicia J. ;

Rezayat, Amir ;

Starner, Timothy D. ;

Sugandha, Shajan P. ;

Sun, Hongtao ;

Quinney, Nancy ;

Donaldson, Scott H. ;

Rowe, Steven M. ;

Gabriel, Sherif E. .

PLOS ONE, 2013, 8 (09)

← 1 2 3 4 5 6 7 8 9 10 →