Advances in the Treatment of Food Allergy Sublingual and Epicutaneous Immunotherapy

被引：18

作者：

Sindher, Sayantani ^{[1
]}

Fleischer, David M. ^{[2
]}

Spergel, Jonathan M. ^{[1
]}

机构：

[1] Univ Penn, Childrens Hosp Philadelphia, Perelman Sch Med, Div Allergy & Immunol,Dept Pediat, Philadelphia, PA 19104 USA

[2] Univ Colorado, Denver Sch Med, Childrens Hosp Colorado, Sect Allergy,Dept Pediat, Aurora, CO 80045 USA

来源：

IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA | 2016年 / 36卷 / 01期

关键词：

Allergen immunotherapy (AIT); Sublingual immunotherapy (SLIT); Epicutaneous immunotherapy (EPIT); Food allergy; Desensitization; Oral tolerance; Sustained unresponsiveness; REGULATORY T-CELLS; PEANUT ALLERGY; ORAL IMMUNOTHERAPY; DOUBLE-BLIND; MULTICENTER TRIAL; NATURAL-HISTORY; SENSITIZED MICE; MILK ALLERGY; INTACT SKIN; KIWI FRUIT;

D O I：

10.1016/j.iac.2015.08.008

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Food allergies continue to increase in prevalence. Allergen immunotherapy has the most potential in treating food allergy. Oral immunotherapy, though efficacious, has a high rate of adverse reactions. Sublingual immunotherapy (SLIT) and epicutaneous immunotherapy (EPIT) have emerged in the search for safer therapeutic options and can successfully desensitize patients with food allergies. SLIT uses the tolerogenic environment of the oral mucosa and epicutaneous immunotherapy (EPIT) uses the immune cells of the epidermis to transport antigens to afferent lymph nodes to activate immune responses. More research is needed to define optimal doses and administration protocols.

引用

页码：39 / +

页数：17

共 52 条

[1] Mechanisms and treatment of allergic disease in the big picture of regulatory T cells [J].

Akdis, Cezmi A. ;

Akdis, Muebeccel .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2009, 123 (04) :735-746

[2] Mechanisms of allergen-specific immunotherapy: Multiple suppressor factors at work in immune tolerance to allergens [J].

Akdis, Muebeccel ;

Akdis, Cezmi A. .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2014, 133 (03) :621-631

[3] Sublingual immunotherapy induces IL-10-producing T regulatory cells, allergen-specific T-cell tolerance, and immune deviation [J].

Bohle, Barbara ;

Kinaciyan, Tamar ;

Gerstmayr, Marianne ;

Radakovics, Astrid ;

Jahn-Schmid, Beatrice ;

Ebner, Christof .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2007, 120 (03) :707-713

[4]

Bousquet J, 1998, ALLERGY, V53, P4

[5] Allergic rhinitis and its impact on asthma [J].

Bousquet, J ;

van Cauwenberge, P ;

Khaltaev, N ;

Ait-Khaled, N ;

Annesi-Maesano, I ;

Bachert, C ;

Baena-Cagnani, C ;

Bateman, E ;

Bonini, S ;

Canonica, GW ;

Carlsen, KH ;

Demoly, P ;

Durham, SR ;

Enarson, D ;

Fokkens, WJ ;

van Wijk, RG ;

Howarth, P ;

Ivanova, NA ;

Kemp, JP ;

Klossek, JM ;

Lockey, RF ;

Lund, V ;

Mackay, I ;

Malling, HJ ;

Meltzer, EO ;

Mygind, N ;

Okunda, M ;

Pawankar, R ;

Price, D ;

Scadding, GK ;

Simons, FER ;

Szczeklik, A ;

Valovirta, E ;

Vignola, AM ;

Wang, DY ;

Warner, JO ;

Weiss, KB .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2001, 108 (05) :S147-S334

[6] Food Allergy Among Children in the United States [J].

Branum, Amy M. ;

Lukacs, Susan L. .

PEDIATRICS, 2009, 124 (06) :1549-1555

[7] Sublingual immunotherapy for peanut allergy: Long-term follow-up of a randomized multicenter trial [J].

Burks, A. Wesley ;

Wood, Robert A. ;

Jones, Stacie M. ;

Sicherer, Scott H. ;

Fleischer, David M. ;

Scurlock, Amy M. ;

Vickery, Brian P. ;

Liu, Andrew H. ;

Henning, Alice K. ;

Lindblad, Robert ;

Dawson, Peter ;

Plaut, Marshall ;

Sampson, Hugh A. .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2015, 135 (05) :1240-U648

[8]

Canonica GW, 2009, ALLERGY, V64, P1, DOI 10.1111/j.1398-9995.2009.02309.x

[9] Sublingual Immunotherapy: Recent Advances [J].

Compalati, Enrico ;

Braido, Fulvio ;

Canonica, Giorgio Walter .

ALLERGOLOGY INTERNATIONAL, 2013, 62 (04) :415-423

[10]

DBV Technologies, 2015, EUR AC ALL CLIN IMM

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