Synthesis of 2,4,6-trisubstituted pyrimidine and triazine heterocycles as antileishmanial agents

被引：76
|
作者：
Sunduru, Naresh
Agarwal, Anu
Katiyar, Sanjay Babu
Nishi
Goyal, Neena
Gupta, Suman
Chauhan, Prem M. S. [1 ]
机构：
[1] Cent Drug Res Inst, Div Med Chem, Lucknow 226001, Uttar Pradesh, India
[2] Cent Drug Res Inst, Div Parasitol, Lucknow 226001, Uttar Pradesh, India
[3] Cent Drug Res Inst, Div Biochem, Lucknow 226001, Uttar Pradesh, India
来源：
BIOORGANIC & MEDICINAL CHEMISTRY | 2006年 / 14卷 / 23期
关键词：
dihydrofolate reductase; pyrimidine; triazine; antileishmanial agents;
D O I：
10.1016/j.bmc.2006.08.009
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A series of 2,4,6 trisubstituted pyrimidines and triazines have been synthesized and screened for its in vitro antileishmanial activity profile in promastigote model. Nine compounds have shown > 94% inhibition against promastigotes at a concentration of 10 mu g/mL. (c) 2006 Elsevier Ltd. All rights reserved.
引用
收藏
页码：7706 / 7715
页数：10
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