Electrospun Ribbon-Like Microfiber Films of a Novel Guanidine-Based ABA Triblock Copolymer: Fabrication, Antibacterial Activity, and Cytotoxicity

被引：7

作者：

Zhang, Hao ^{[1
,2
]}

Liu, Yanna ^{[3
]}

Cui, Kun ^{[1
]}

Zhao, Qiaoling ^{[1
]}

Huang, Jin ^{[1
]}

Mao, Shuhong ^{[3
]}

Jiang, Tao ^{[2
]}

Ma, Zhi ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Organ Chem, Ctr Excellence Mol Synth, Key Lab Synthet & Self Assembly Chem Organ Funct, Shanghai 200032, Peoples R China

[2] Tianjin Univ Sci & Technol, Coll Chem Engn & Mat Sci, Tianjin 300457, Peoples R China

[3] Tianjin Univ Sci & Technol, Coll Biotechnol, Tianjin 300457, Peoples R China

来源：

MACROMOLECULAR CHEMISTRY AND PHYSICS | 2019年 / 220卷 / 13期

基金：

中国国家自然科学基金;

关键词：

antibacterial films; cytotoxicity; electrospinning; ribbon-like microfibers; tissue scaffolds; POLYSTYRENE NANOFIBER MATERIALS; DRUG-DELIVERY; POLYMER; FIBERS; MORPHOLOGY; PROLIFERATION; OPTIMIZATION; MEMBRANES; REMOVAL; JETS;

D O I：

10.1002/macp.201900138

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Guanidine-based polymers have emerged as potential candidates for antibacterial agents and materials due to their high antibacterial property, no cytotoxicity, no bacterial resistance, and so on. A novel antimicrobial poly(methacryl guanidine hydrochloride)-block-polystyrene-block-poly(methacryl guanidine hydrochloride) (PMAGH-b-PS-b-PMAGH) is electrospun to ribbon-like microfiber films for the first time. The electrospinning process parameters affecting structure and morphology of the ribbon-like microfibers, including concentration, voltage, and feeding rate are systematically investigated. The mechanism inducing the formation of ribbon-like fibers with a positively charged polymer is proposed and verified. PMAGH-b-PS-b-PMAGH microfiber films can inhibit 96% of Escherichia coli and 92% of Bacillus subtilis, and are not cytotoxic to mouse embryonic fibroblasts, but instead, provide a larger surface area for cell adherent growth.

引用

页数：8