Serotonergic modulation of psychological stress-induced alteration in synaptic plasticity in the rat hippocampal CA1 field

被引：18
作者：
Matsumoto, M
Togashi, H
Ohashi, S
Tachibana, K
Yamaguchi, T
Yoshioka, M
机构：
[1] Hokkaido Univ, Grad Sch Med, Dept Neuropharmacol, Kita Ku, Sapporo, Hokkaido 0608638, Japan
[2] Hokkaido Univ, Grad Sch Med, Dept Anesthesiol & Crit Care Med, Kita Ku, Sapporo, Hokkaido 0608638, Japan
来源：
BRAIN RESEARCH | 2004年 / 1022卷 / 1-2期
关键词：
serotonin; synaptic plasticity; hippocampus; contextual fear conditioning; freezing behavior;
D O I：
10.1016/j.brainres.2004.06.078
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
In order to elucidate possible involvement of the serotonergic neuronal system in the stress-induced alteration in synaptic plasticity, the effects of contextual fear conditioning (CFC) on long-term potentiation (LTP) in the hippocampal CA1 field were examined in 5-HT-depleted rats by pretreatment with 5,7-dihydroxytryptamine (5,7-DHT, 200 μg/rat, i.c.v.). LTP induction was suppressed by footshock (FS) stimulation in 5-HT-lesioned rats and vehicle-treated controls. When rats were exposed to CFC, which was received 24 h after FS stimulation, LTP was also blocked in both-treated groups. CFC-induced impairment of LTP, however, significantly attenuated in 5-HT-lesioned rats when compared with that in controls. Fear-related freezing behavior after FS stimulation occurred similarly in both treated groups, whereas the behavior observed during exposure to CFC significantly reduced in 5-HT-lesioned rats. These results suggest that the serotonergic mechanism is involved in the psychological stress-induced alteration in synaptic plasticity, which appears to be associated with fear-related behavior. © 2004 Elsevier B.V. All rights reserved.
引用
收藏
页码：221 / 225
页数：5
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