The purpose of this study was to examine the effects of pre-university adiposity and physical fitness on changes of body weight and adiposity during the freshmen year. Twenty-nine freshmen (sixteen females and thirteen males) completed the study. Body weight and composition (dual-energy X-ray absorptiometry), waist circumference (WC), energy intake (7d food diary) and activity-related energy expenditure (accelerometry) were measured in September, December and at the end of March. Peak oxygen uptake (V-O2peak) was assessed at baseline only. Significant increases in body weight (19 (SD 2.0) kg, P<005), BMI (0.6 (SD 0.7) kg/m(2), P<0.05), WC (2.7 (SD 3.0) cm, P<0.05) and % body fat (BF) (3.1 (SD 2.3) %, P<0.01) were noted in males, especially over the course of the first semester. No significant changes were observed in females. Results from correlation analyses showed that, baseline %BF was negatively associated with changes in body weight (r -0-53, P<0.01) and %BF (r -0-41, P<0.05) over the academic year. Baseline %BF predicted 27% (P<0.05) of the change in weight. Alcohol intake explained 34% (P<0.01) and 17% (P<0.05) of the changes in WC and %BF, respectively. The change in body weight and %BF were also positively associated with baseline V-O2peak (r 0.51, P<0.01; r 0.48, P<0.01, respectively) while dietary restraint was negatively related to the changes in %BF (r -0.43, P<0.05). In summary, lower pre-university adiposity, higher V-O2peak and higher alcohol intake are associated with greater changes in adiposity and body weight during the freshmen year.