Reliability of regulatory networks and its evolution

被引：7

作者：

Braunewell, Stefan ^{[1
]}

Bornholdt, Stefan ^{[1
]}

机构：

[1] Univ Bremen, Inst Theoret Phys, D-28359 Bremen, Germany

来源：

JOURNAL OF THEORETICAL BIOLOGY | 2009年 / 258卷 / 04期

关键词：

Gene regulatory networks; Evolution models; Boolean networks; Computer simulation; Robustness; SEGMENT POLARITY NETWORK; BIOLOGICAL NETWORKS; GENE-EXPRESSION; BOOLEAN MODELS; ROBUSTNESS; NOISE; TOPOLOGY; YEAST; STOCHASTICITY; CONSEQUENCES;

D O I：

10.1016/j.jtbi.2009.02.013

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The problem of reliability of the dynamics in biological regulatory networks is studied in the framework of a generalized Boolean network model with continuous timing and noise. Using well-known artificial genetic networks such as the repressilator, we discuss concepts of reliability of rhythmic attractors. In a simple evolution process we investigate how overall network structure affects the reliability of the dynamics. In the course of the evolution, networks are selected for reliable dynamics. We find that most networks can be easily evolved towards reliable functioning while preserving the original function. (c) 2009 Elsevier Ltd. All rights reserved.

引用

页码：502 / 512

页数：11

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