Other Iatrogenic Immunodeficiency-Associated Lymphoproliferative Disorders, Diffuse Large B-Cell Lymphoma Type, in a Patient with Behcet's Disease Treated with Cyclosporine A

被引：1

作者：

Urano, Yuka ^{[1
]}

Ohe, Rintaro ^{[1
]}

Yamada, Akane ^{[2
]}

Kabasawa, Takanobu ^{[1
]}

Suzuki, Kazushi ^{[1
]}

Kitaoka, Takumi ^{[1
]}

Tamazawa, Nobuyuki ^{[1
]}

Aung, Naing Ye ^{[1
]}

Utsunomiya, Aya ^{[1
]}

Toubai, Tomomi ^{[2
]}

Ishizawa, Kenichi ^{[2
]}

机构：

[1] Yamagata Univ, Fac Med, Dept Pathol Diagnost, Yamagata, Japan

[2] Yamagata Univ, Fac Med, Dept Neurol Hematol Metab Endocrinol & Diabetol, Yamagata, Japan

来源：

CASE REPORTS IN ONCOLOGY | 2020年 / 13卷 / 03期

基金：

日本学术振兴会;

关键词：

Behcet's disease; Cyclosporine A; Lymph node; Diffuse large B-cell lymphoma; Epstein-Barr virus; MALIGNANCY; TACROLIMUS;

D O I：

10.1159/000510362

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A 40-year-old man had been treated for Behcet's disease (BD) with cyclosporine A (CsA) for 14 years. He presented multiple lymphadenopathies with fever. Histological examination of surgical biopsy showed other iatrogenic immunodeficiency-associated lymphoproliferative disorders, diffuse large B-cell lymphoma type with positivity for Epstein-Barr virus encoding RNA-1 (EBER-1). BCL2-IgH, BCL6-IgH, and MYC-IgH translocations were not detected. CsA was stopped, and R-CHOP therapy was initiated. However, his lymphoma was chemotherapy resistant and rapidly progressed. To the best of our knowledge, this is the first case of diffuse large B-cell lymphoma that occurred in a BD patient treated with CsA reported in English. Both BD and CsA are associated with the pathogenesis of lymphoma. We also describe extremely rare cases in the form of a literature review. (c) 2020 The Author(s). Published by S. Karger AG, Basel

引用

页码：1145 / 1151

页数：7

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