Antimicrobial activity and cytotoxicity towards cancer cells of Melaleuca alternifolia (tea tree) oil

被引：41
作者：
Liu, Xia [1 ,2 ]
Zu, Yuangang [1 ,2 ]
Fu, Yujie [1 ,2 ]
Yao, Liping [1 ,2 ]
Gu, Chengbo [1 ,2 ]
Wang, Wei [1 ,2 ]
Efferth, Thomas [3 ]
机构：
[1] NE Forestry Univ, Minist Educ, Key Lab Forest Plant Ecol, Harbin 150040, Peoples R China
[2] NE Forestry Univ, Minist Educ, Engn Res Ctr Forest Biopreparat, Harbin 150040, Peoples R China
[3] German Canc Res Ctr, D-69120 Heidelberg, Germany
来源：
EUROPEAN FOOD RESEARCH AND TECHNOLOGY | 2009年 / 229卷 / 02期
基金：
中国国家自然科学基金;
关键词：
Antimicrobial activity; Cell cycle; Cytotoxicity to tumor cells; Melaleuca alternifolia (Myrtaceae); Tea tree oil; IN-VITRO; ANTIBACTERIAL ACTIVITY; MAJOR COMPONENTS; BETA-PINENE; MONOTERPENES; MICROSCOPY; MECHANISM; TOXICITY; LEAVES;
D O I：
10.1007/s00217-009-1057-5
中图分类号：
TS2 [食品工业];
学科分类号：
0832 ;
摘要：
Antimicrobial and in vitro anti-tumor activities of Melaleuca alternifolia (tea tree) oil (TTO) were analyzed. The results indicated that TTO possessed significant antimicrobial activity towards all tested microorganisms except Aspergillus niger. The minimum inhibitory concentration (MIC) of TTO towards Staphylococcus epidermidi, Bacillus subtilis, Escherichia coli and Candida albicans was 0.25% (v/v). Time kinetic experiments showed that Staphylococcus epidermidi, Escherichia coli and Candida albicans were completely killed after exposure to TTO at 2x MIC for 1, 4 and 8 h, repectively. TTO also exhibited strong cytotoxicity towards human lung cancer cell line (A549), human breast cancer cell line (MCF-7) and human prostate cancer cell line (PC-3). The IC50 values obtained were 0.012% (v/v), 0.031% (v/v) and 0.037% (v/v), respectively. Flow cytometric analysis demonstrated that TTO restrained the cell cycle progression of PC-3 and MCF-7 cell lines at the G0/G1 phase and A549 cell at the S phase.
引用
收藏
页码：247 / 253
页数：7
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