Free fatty acid metabolism in human skeletal muscle is regulated by PPARγ and RXR agonists

被引：0
作者：
Ciaraldi, TP
Cha, BS
Park, KS
Carter, L
Mudaliar, SR
Henry, RR
机构：
[1] VA San Diego Healthcare Syst, San Diego, CA 92161 USA
[2] Univ Calif San Diego, Dept Med, La Jolla, CA 92093 USA
来源：
LIPIDS AND INSULIN RESISTANCE: THE ROLE OF FATTY ACID METABOLISM AND FUEL PARTITIONING | 2002年 / 967卷
关键词：
free fatty acids (FFA); metabolism; oxidation; muscle; PPAR gamma; RXR; lipid; insulin;
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Free fatty acid (FFA) oxidation in human skeletal muscle cells can be stimulated, both independently and in a synergistic manner, by agonists for PPARgamma and RXR. Increased FFA disposal in muscle through augmented oxidation could reduce intramyocellular lipid accumulation. The abilities of such agents to improve glucose tolerance and insulin action may thus involve effects on both glucose and FFA metabolism.
引用
收藏
页码：66 / 70
页数：5
相关论文
共 12 条
  • [11] Intramuscular triglyceride and muscle insulin sensitivity: Evidence for a relationship in nondiabetic subjects
    Phillips, DIW
    Caddy, S
    Ilic, V
    Fielding, BA
    Frayn, KN
    Borthwick, AC
    Taylor, R
    [J]. METABOLISM-CLINICAL AND EXPERIMENTAL, 1996, 45 (08): : 947 - 950
  • [12] Markers of capacity to utilize fatty acids in human skeletal muscle: relation to insulin resistance and obesity and effects of weight loss
    Simoneau, JA
    Veerkamp, JH
    Turcotte, LP
    Kelley, DE
    [J]. FASEB JOURNAL, 1999, 13 (14) : 2051 - 2060
12