Facile synthesis of a reduction-responsive amphiphilic triblock polymer via a selective thiol-disulfide exchange reaction

被引：16
作者：
Liu, Xiangyu [1 ]
He, Jingwen [1 ]
Hu, Ding [1 ]
Niu, Yile [1 ]
Xia, Xinnian [1 ]
Lu, Yanbing [1 ]
机构：
[1] Hunan Univ, Coll Chem & Chem Engn, Changsha 410082, Hunan, Peoples R China
来源：
RSC ADVANCES | 2014年 / 4卷 / 90期
关键词：
CROSS-LINKED MICELLES; GLUTATHIONE; LIGHT; NANOPARTICLES;
D O I：
10.1039/c4ra07792j
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A reduction-responsive amphiphilic triblock copolymer mPEG-b-PDS-b-mPEG was synthesized via polycondensation between a dithiol and dipyridyl disulfide, followed by a selective thiol-disulfide exchange reaction. The reduction-triggered release of Nile Red by DTT was further demonstrated using fluorescence spectroscopy.
引用
收藏
页码：48897 / 48900
页数：4
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  • [1] Doxycycline hydrogels with reversible disulfide crosslinks for dermal wound healing of mustard injuries
    Anumolu, SivaNaga S.
    Menjoge, Anupa R.
    Deshmukh, Manjeet
    Gerecke, Donald
    Stein, Stanley
    Laskin, Jeffrey
    Sinko, Patrick J.
    [J]. BIOMATERIALS, 2011, 32 (04) : 1204 - 1217
  • [2] Telechelic Poly(disulfide)s and Related Block Copolymer
    Basak, Dipankar
    Kumar, Rajan
    Ghosh, Suhrit
    [J]. MACROMOLECULAR RAPID COMMUNICATIONS, 2014, 35 (15) : 1340 - 1344
  • [3] Reversibly light-responsive micelles constructed via a simple modification of hyperbranched polymers with chromophores
    Chen, Chao-Jian
    Jin, Qiao
    Liu, Gong-Yan
    Li, Dan-Dan
    Wang, Jin-Lei
    Ji, Jian
    [J]. POLYMER, 2012, 53 (17) : 3695 - 3703
  • [4] Photo-responsive, biocompatible polymeric micelles self-assembled from hyperbranched polyphosphate-based polymers
    Chen, Chaojian
    Liu, Gongyan
    Liu, Xiangsheng
    Pang, Shaopeng
    Zhu, Congshan
    Lv, Liping
    Ji, Jian
    [J]. POLYMER CHEMISTRY, 2011, 2 (06) : 1389 - 1397
  • [5] pH and Reduction Dual-Sensitive Copolymeric Micelles for Intracellular Doxorubicin Delivery
    Chen, Jun
    Qiu, Xiaozhong
    Ouyang, Jun
    Kong, Jiming
    Zhong, Wen
    Xing, Malcolm M. Q.
    [J]. BIOMACROMOLECULES, 2011, 12 (10) : 3601 - 3611
  • [6] Reduction-responsive cross-linked micelles based on PEGylated polypeptides prepared via click chemistry
    Cheng, Yilong
    He, Chaoliang
    Xiao, Chunsheng
    Ding, Jianxun
    Ren, Kaixuan
    Yu, Shuangjiang
    Zhuang, Xiuli
    Chen, Xuesi
    [J]. POLYMER CHEMISTRY, 2013, 4 (13) : 3851 - 3858
  • [7] Poly(L-aspartamide)-Based Reduction-Sensitive Micelles as Nanocarriers to Improve Doxorubicin Content in Cell Nuclei and to Enhance Antitumor Activity
    Cui, Can
    Xue, Ya-Nan
    Wu, Ming
    Zhang, Yang
    Yu, Ping
    Liu, Lei
    Zhuo, Ren-Xi
    Huang, Shi-Wen
    [J]. MACROMOLECULAR BIOSCIENCE, 2013, 13 (08) : 1036 - 1047
  • [8] Multiple stimuli-responsive polymeric micelles for controlled release
    Dong, Jie
    Wang, Yani
    Zhang, Jian
    Zhan, Xiaowei
    Zhu, Siquan
    Yang, Huai
    Wang, Guojie
    [J]. SOFT MATTER, 2013, 9 (02) : 370 - 373
  • [9] Facile preparation of shell crosslinked micelles for redox-responsive anticancer drug release
    Gao, Lilong
    Luo, Qiaojie
    Wang, Ying
    Du, Hong
    Li, Xiaodong
    Shen, Zhiquan
    Zhu, Weipu
    [J]. RSC ADVANCES, 2014, 4 (08): : 4177 - 4180
  • [10] Synthetic micelle sensitive to IR light via a two-photon process
    Goodwin, AP
    Mynar, JL
    Ma, YZ
    Fleming, GR
    Fréchet, JMJ
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2005, 127 (28) : 9952 - 9953
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