Balance of Yin and Yang: Ubiquitylation-mediated regulation of p53 and c-Myc

被引：68

作者：

Dai, Mu-Shui ^{[1
]}

Jin, Yetao ^{[1
]}

Gallegos, Jayme R. ^{[1
]}

Lu, Hua ^{[1
]}

机构：

[1] Oregon Hlth & Sci Univ, Dept Biochem & Mol Biol, Sch Med, Portland, OR 97239 USA

来源：

NEOPLASIA | 2006年 / 8卷 / 08期

关键词：

p53; c-Myc; ubiquitylation; Yin and Yang; oncogenesis;

D O I：

10.1593/neo.06334

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Protein ubiquitylation has been demonstrated to play a vital role not only in mediating protein turnover but also in modulating protein activity. The stability and activity of the tumor suppressor p53 and of the oncoprotein c-Myc are no exception. Both are regulated through independent ubiquitylation by several E3 ubiquitin ligases. Interestingly, p53 and c-Myc are functionally connected by some of these E3 enzymes and their regulator ARF, although these proteins play opposite roles in controlling cell growth and proliferation. The balance of this complex ubiquitylation network and its disruption during oncogenesis will be the topics of this review.

引用

页码：630 / 644

页数：15

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