Asymmetric synthesis of (S)-tylophorine and (S)-cryptopleurine via one-pot Curtius rearrangement and Friedel-Crafts reaction tandem sequence

被引：15
作者：
Chen, Fazhong [1 ]
Su, Bo [1 ]
Wang, Qingmin [1 ]
机构：
[1] Nankai Univ, Collaborat Innovat Ctr Chem Sci & Engn Tianjin, Res Inst Elementoorgan Chem, State Key Lab Elementoorgan Chem, Tianjin 300071, Peoples R China
来源：
ORGANIC CHEMISTRY FRONTIERS | 2014年 / 1卷 / 06期
基金：
中国国家自然科学基金;
关键词：
PHENANTHROINDOLIZIDINE ALKALOIDS; PHENANTHROQUINOLIZIDINE ALKALOIDS; DERIVATIVES; PROGRESS; PROLINE; ANALOGS; AGENTS; AZIDES; ACID;
D O I：
10.1039/c4qo00084f
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A general and practical enantioselective synthetic approach to both the phenanthroindolizidine and phenanthroquinolizidine alkaloids (S)-tylophorine and (S)-cryptopleurine was developed, which features a stereoselective alkylation and a one-pot Curtius reaction rearrangement/intramolecular cyclization cascade sequence.
引用
收藏
页码：674 / 677
页数：4
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