Role and function of matrix metalloproteinases in the differentiation and biological characterization of mesenchymal stem cells

被引:115
作者
Mannello, Ferdinando
Tonti, Gaetana A. M.
Bagnara, Gian Paolo
Papa, Stefano
机构
[1] Univ Urbino, Fac SMFN, Inst Hist & Lab Anal, I-61029 Urbino, PU, Italy
[2] Univ Urbino, Inst Morphol Sci, Ctr Cytometry, I-61029 Urbino, PU, Italy
[3] Univ Bologna, Dept Histol Embryol & Appl BIol, Bologna, Italy
[4] Univ Bologna, Stem Cell Res Ctr, Bologna, Italy
关键词
mesenchymal stem cell; matrix metalloproteinase; tissue inhibitor of metalloproteinases gene and protein expression; differentiation; osteogenesis; chondrogenesis; adipogenesis neurogenesis; myogenesis;
D O I
10.1634/stemcells.2005-0333
中图分类号
Q813 [细胞工程];
学科分类号
摘要
Matrix metalloproteinases (MMPs), known as matrixins, are Ca- and Zn-dependent endoproteinases involved in a wide variety of developmental and disease-associated processes, proving to be crucial protagonists in many physiological and pathological mechanisms. The ability of NMPs to alter, by limited proteolysis and through the fine control of tissue inhibitors of metalloproteinases, the activity or function of numerous proteins, enzymes, and receptors suggests that they are also involved in various important cellular functions during development. In this review, we focus on the differentiation of mesenchymal stem cells (including those of the myoblastic, osteoblastic, chondroblastic, neural, and apidoblastic lineages) and the possible, if unexpected, biological significance of MMPs in its regulation. The MMP system has been implicated in several differentiation events that suggests that it mediates the proliferative and prodifferentiating effect of the matrixin proteolytic cascade. We summarize these regulatory effects of MMPs on the differentiation of mesenchymal stem cells and hypothesize on the function of MMPs in the stem cell differentiation processes.
引用
收藏
页码:475 / 481
页数:7
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