Energy sensors and reproductive hypothalamo-pituitary ovarian axis (HPO) in female mammals: Role of mTOR (mammalian target of rapamycin), AMPK (AMP-activated protein kinase) and SIRT1 (Sirtuin 1)

被引：23
|
作者：
Estienne, Anthony [1 ,2 ,3 ,4 ]
Bongrani, Alice [1 ,2 ,3 ,4 ]
Rame, Christelle [1 ,2 ,3 ,4 ]
Kurowska, Patrycja [5 ]
Blaszczyk, Klaudia [5 ]
Rak, Agnieszka [5 ]
Ducluzeau, Pierre-Henri [1 ,2 ,3 ,4 ]
Froment, Pascal [1 ,2 ,3 ,4 ]
Dupont, Joelle [1 ,2 ,3 ,4 ]
机构：
[1] INRAE UMR85 Physiol Reprod & Comportements, F-37380 Nouzilly, France
[2] CNRS UMR7247 Physiol Reprod & Comportements, F-37380 Nouzilly, France
[3] Univ Francois Rabelais Tours, F-37041 Tours, France
[4] IFCE, F-37380 Nouzilly, France
[5] Jagiellonian Univ Krakow, Inst Zool & Biomed Res, Dept Physiol & Toxicol Reprod, PL-30387 Krakow, Poland
来源：
MOLECULAR AND CELLULAR ENDOCRINOLOGY | 2021年 / 521卷
关键词：
Energy metabolism; AMPK; mTOR; SIRTUIN; 1; Female fertility; Ovary; Hypothalamus; Pituitary; HUMAN GRANULOSA-CELLS; KAPPA-B P50/P65; IN-VITRO; MOUSE OOCYTES; HORMONE SECRETION; PROGESTERONE SECRETION; INSULIN-RESISTANCE; MEIOTIC RESUMPTION; HYPOTHALAMIC MTOR; GONADAL-FUNCTION;
D O I：
10.1016/j.mce.2020.111113
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
In female, energy metabolism influences reproductive function by modulating the Hypothalamic Pituitary Ovarian axis including the hypothalamic GnRH neuronal network, the pituitary gonadotropin secretion and the ovarian follicle growth and steroidogenesis. Several hormones and neuropeptides or metabolites are important signals between energy balance and reproduction. These energy sensors mediate their action on reproductive cells through specific kinases or signaling pathways. This review focuses on the role of three main enzymes-specifically, mTOR, AMPK, and SIRT1 at the hypothalamic pituitary and ovarian axis in normal female fertility and then we discuss their possible involvement in some women reproductive disorders known to be associated with metabolic complications, such as polycystic ovary syndrome (PCOS) and premature ovarian failure (POF).
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页数：12
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