Proline Might Have Been the First Amino Acid in the Primitive Genetic Code

被引：2

作者：

Komatsu, Reina ^{[1
]}

Sawada, Risa ^{[1
]}

Umehara, Takuya ^{[1
]}

Tamura, Koji ^{[1
,2
]}

机构：

[1] Tokyo Univ Sci, Dept Biol Sci & Technol, Katsushika Ku, Tokyo 1258585, Japan

[2] Tokyo Univ Sci, Res Inst Sci & Technol, Noda, Chiba 2788510, Japan

来源：

JOURNAL OF MOLECULAR EVOLUTION | 2014年 / 78卷 / 06期

关键词：

Origin; Genetic code; Proline; tRNA; Anticodon; G-quartet; ORIGIN; TETRAPLEX; SEQUENCES; EVOLUTION; DNA;

D O I：

10.1007/s00239-014-9629-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Stereochemical assignment of amino acids and corresponding codons or anticodons has not been successful so far. Here, we focused on proline and GGG (anticodon of tRNA(Pro)) and investigated their mutual interaction. Circular dichroism spectroscopy revealed that guanosine nucleotides (GG, GGG) formed G-quartet structures. The structures were destroyed by adding high concentrations of proline. We propose that the possibility of the reversible proline/G-quartet interaction could have contributed to the specific assignment of proline on GGG and that this coding could have been the first in the genetic code.

引用

页码：310 / 312

页数：3

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