Efficient Synthesis of Pyridine [2,3-d]pyrimidine Derivatives by Catalyst-free Tandem Cyclization Under Microwave Irradiation

被引：1

作者：

Lin, Junjie ^{[1
]}

Wang, Shuang ^{[1
]}

Li, Weiqiang ^{[1
]}

Cui, Xin ^{[1
]}

Huang, Chao ^{[1
]}

机构：

[1] Yunnan Minzhu Univ, Sch Chem & Environm, Kunming 650503, Yunnan, Peoples R China

来源：

CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE | 2020年 / 41卷 / 12期

基金：

中国国家自然科学基金;

关键词：

alpha; beta-Unsaturated ketone; Pyridine; 2; 3-d; pyrimidine; Microwave irradiation; Catalyst-free; Tandem cyclization; CHEMISTRY; ACID;

D O I：

10.7503/cjcu20200563

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

This work presents a highly efficient and simple method for the synthesis of pyridine [2, 3-d] pyrimidine derivatives. This method took the alpha, beta-unsaturated ketones compounds and 1, 3-dimethyl-6-aminouracil as raw material, 28 pyridine [2, 3-d] pyrimidine derivatives were synthesized by microwave irradiation high-efficiency tandem cyclization in 5-15 min without catalyst, including 21 compounds did not see the literature. This method has the characteristics of simple and easy raw materials, high green efficiency, high bonding efficiency and simple post-treatment.

引用

页码：2749 / 2758

页数：10

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