PET/MR in invasive ductal breast cancer: correlation between imaging markers and histological phenotype

被引：58

作者：

Catalano, Onofrio Antonio ^{[1
,2
]}

Horn, Gary Lloyd ^{[3
]}

Signore, Alberto ^{[4
]}

Iannace, Carlo ^{[5
]}

Lepore, Maria ^{[6
]}

Vangel, Mark ^{[7
]}

Luongo, Angelo ^{[8
]}

Catalano, Marco ^{[9
,11
]}

Lehman, Constance ^{[10
]}

Salvatore, Marco

Soricelli, Andrea ^{[12
]}

Catana, Ciprian ^{[13
]}

Mahmood, Umar ^{[14
]}

Rosen, Bruce Robert ^{[13
]}

机构：

[1] Massachusetts Gen Hosp, Harvard Med Sch, Martinos Ctr Biomed Imaging, 149 13th St, Charlestown, MA 02129 USA

[2] Massachusetts Gen Hosp, Harvard Med Sch, Abdominal Imaging, 55 Fruit St, Boston, MA 02114 USA

[3] Univ Texas Med Branch, Dept Radiol, 301 Univ Blvd, Galveston, TX 77555 USA

[4] Univ Roma La Sapienza, Nucl Med Unit, Viale Policlin 5, I-00161 Rome, Italy

[5] Osped Moscati, Breast Unit, I-83010 Avellino, Italy

[6] Osped Moscati, Dept Pathol, I-83010 Avellino, Italy

[7] Massachusetts Gen Hosp, Harvard Med Sch, Martinos Ctr Biomed Imaging, Dept Biostat, 149 13th St, Charlestown, MA 02129 USA

[8] Gamma Cord, Dept Radiol, I-82100 Benevento, Italy

[9] Univ Naples Federico II, Dept Radiol, I-80131 Naples, Italy

[10] Massachusetts Gen Hosp, Harvard Med Sch, Breast Imaging, 55 Fruit St, Boston, MA 02114 USA

[11] SDN, Diagnost Imaging, Via Gianturco 113, I-80131 Naples, Italy

[12] Univ Naples Parthenope, Diagnost Imaging, I-80131 Naples, Italy

[13] Massachusetts Gen Hosp, Martinos Ctr Biomed Imaging, Harvard Med Sch, Dept Radiol, 149 13th St, Charlestown, MA 02129 USA

[14] Massachusetts Gen Hosp, Martinos Ctr Biomed Imaging, Harvard Med Sch, Precis Med & Radiol, 149 13th St, Charlestown, MA 02129 USA

来源：

BRITISH JOURNAL OF CANCER | 2017年 / 116卷 / 07期

关键词：

PET/MR; breast cancer; phenotypes; receptor expression; PET; MR; APPARENT DIFFUSION-COEFFICIENT; PATHOLOGISTS GUIDELINE RECOMMENDATIONS; STANDARDIZED UPTAKE VALUES; CONTRAST-ENHANCED MRI; PROGNOSTIC-FACTORS; WEIGHTED MRI; FDG-PET/CT; NEOADJUVANT CHEMOTHERAPY; PERFUSION PARAMETERS; ESTROGEN-RECEPTOR;

D O I：

10.1038/bjc.2017.26

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: Differences in genetics and receptor expression (phenotypes) of invasive ductal breast cancer (IDC) impact on prognosis and treatment response. Immunohistochemistry (IHC), the most used technique for IDC phenotyping, has some limitations including its invasiveness. We explored the possibility of contrast-enhanced positron emission tomography magnetic resonance (CE-FDG PET/MR) to discriminate IDC phenotypes. Methods: 21 IDC patients with IHC assessment of oestrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor-2 (HER2), and antigen Ki-67 (Ki67) underwent CE-FDG PET/MR. Magnetic resonance-perfusion biomarkers, apparent diffusion coefficient (ADC), and standard uptake value (SUV) were compared with IHC markers and phenotypes, using a Student's t-test and one-way ANOVA. Results: ER/PR - tumours demonstrated higher Kep(mean) and SUVmax than ER or PR+ tumours. HER2 - tumours displayed higher ADC(mean), Kep(mean), and SUVmax than HER2+tumours. Only ADC(mean) discriminated Ki67 <= 14% tumours (lower ADC(mean)) from Ki67 > 14% tumours. PET/MR biomarkers correlated with IHC phenotype in 13 out of 21 patients (62%; P = 0.001). Conclusions: Positron emission tomography magnetic resonance might non-invasively help discriminate IDC phenotypes, helping to optimise individual therapy options.

引用

页码：893 / 902

页数：10

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