Graft Survival Versus Glaucoma Treatment After Penetrating or Descemet Stripping Automated Endothelial Keratoplasty

被引：27

作者：

Ward, Matthew S. ^{[1
]}

Goins, Kenneth M. ^{[1
]}

Greiner, Mark A. ^{[1
]}

Kitzmann, Anna S. ^{[1
]}

Sutphin, John E. ^{[1
,2
]}

Alward, Wallace L. M. ^{[1
]}

Greenlee, Emily C. ^{[1
]}

Kwon, Young H. ^{[1
]}

Zimmerman, M. Bridget ^{[3
]}

Wagoner, Michael D. ^{[1
]}

机构：

[1] Univ Iowa, Dept Ophthalmol & Visual Sci, Iowa City, IA USA

[2] Univ Kansas, Med Ctr, Dept Ophthalmol, Kansas City, KS 66103 USA

[3] Univ Iowa, Sch Publ Hlth, Dept Biostat, Iowa City, IA USA

来源：

CORNEA | 2014年 / 33卷 / 08期

关键词：

penetrating keratoplasty; Descemet stripping automated endothelial keratoplasty; graft survival; glaucoma treatment; RISK-FACTORS; INTRAOCULAR-PRESSURE; ANTIGLAUCOMA DRUGS; EYES; ESCALATION; FAILURE; MANAGEMENT; THERAPY;

D O I：

10.1097/ICO.0000000000000170

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Purpose: The aim of this study was to assess and compare the association of glaucoma therapy with graft survival after performing penetrating keratoplasty (PKP) and Descemet stripping automated endothelial keratoplasty (DSAEK). Methods: A retrospective chart review was performed of cases: primary PKP from January 1, 2003, to December 31, 2005, or primary DSAEK from January 1, 2006, to December 31, 2008. Eyes with a surgical indication of pseudophakic corneal edema were included in the statistical analysis. Eyes were stratified by glaucoma treatment into those with (1) no glaucoma treatment, (2) medical therapy only, or (3) surgical intervention. The main outcome measure was graft survival. Results: Fifty-seven PKP-operated and 156 DSAEK-operated eyes met the inclusion criteria. After PKP and DSAEK, respectively, the 5-year Kaplan-Meier graft survival was 94.7% and 93.8% in eyes with no glaucoma treatment (P > 0.99), 93.8% and 96.3% in eyes with medical therapy only (P > 0.99), and 56.8% and 50% in eyes with surgical intervention (P > 0.99). After both procedures were performed, graft survival was significantly worse in eyes with surgical intervention compared with that in eyes with no glaucoma treatment (P< 0.0001) or in eyes with medical therapy alone (P < 0.0001). Conclusions: PKP and DSAEK have comparable graft survival in eyes without glaucoma management and in those with comparable glaucoma management.

引用

页码：785 / 789

页数：5