LBNP exercise protects aerobic capacity and sprint speed of female twins during 30 days of bed rest

Lee SM, Schneider SM, Boda WL, Watenpaugh DE, Macias BR, Meyer RS, Hargens AR. LBNP exercise protects aerobic capacity and sprint speed of female twins during 30 days of bed rest. J Appl Physiol 106: 919-928, 2009. First published December 26, 2008; doi:10.1152/japplphysiol. 91502.2008.-We have shown previously that treadmill exercise within lower body negative pressure (LBNPex) maintains upright exercise capacity (peak oxygen consumption, (V) over dot O-2peak) in men after 5, 15, and 30 days of bed rest (BR). We hypothesized that LBNPex protects treadmill (V) over dot O-2peak and sprint speed in women during a 30-day BR. Seven sets of female monozygous twins volunteered to participate. Within each twin set, one was randomly assigned to a control group (Con) and performed no countermeasures, and the other was assigned to an exercise group (Ex) and performed a 40-min interval (40 - 80% pre-BR (V) over dot O-2peak) LBNPex (51 +/- 5 mmHg) protocol, plus 5 min of static LBNP, 6 days per week. Before and immediately after BR, subjects completed a 30.5-m sprint test and an upright graded treadmill test to volitional fatigue. These results in women were compared with previously reported reductions in (V) over dot O-2peak and sprint speed in male twins after BR. In women, sprint speed (-8 +/- 2%) and (V) over dot O-2peak (-6 +/- 2%) were not different after BR in the Ex group. In contrast, both sprint speed (-24 +/- 5%) and (V) over dot O-2peak (-16 +/- 3%) were significantly less after BR in the Con group. The effect of BR on sprint speed and (V) over dot O-2peak after BR was not different between women and men. We conclude that treadmill exercise within LBNP protects against BR-induced reductions in (V) over dot O-2peak and sprint speed in women and should prove effective during long-duration spaceflight.