Etiology and Pathogenesis of Psoriasis

被引:156
作者
Boehncke, Wolf-Henning [1 ,2 ]
机构
[1] Univ Hosp Geneva, Dept Dermatol & Venereol, CH-1211 Geneva 14, Switzerland
[2] Univ Geneva, Dept Pathol & Immunol, CH-1206 Geneva, Switzerland
关键词
Psoriasis; Genome-wide association study; Etiology; Pathogenesis; IL-17; T lymphocytes; Dendritic cells; Keratinocytes; GENERALIZED PUSTULAR PSORIASIS; MYOCARDIAL-INFARCTION; METABOLIC SYNDROME; SKIN INFLAMMATION; IL36RN MUTATIONS; PLAQUE PSORIASIS; INNATE IMMUNITY; CROHN-DISEASE; T-CELLS; LOCI;
D O I
10.1016/j.rdc.2015.07.013
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Psoriasis is a common, chronic inflammatory skin disease most often appearing in the form of well-demarcated, scaly plaques. These lesions highlight the fundamental processes underlying its pathogenesis, namely, inflammation and epidermal hyperproliferation. Both phenomena are considered consequences of an intimate interplay between the innate and the adaptive immune system. This concept is supported by results of genetic studies, pointing toward the signaling pathways of nuclear factor-kappa B, interferon-gamma, and interleukin (IL)-23 as well as antigen presentation as central axes of the psoriatic inflammation. Efficacy of biologics targeting tumor necrosis factor-alpha, IL-23, or IL-17 provides further evidence in favor of this model.
引用
收藏
页码:665 / +
页数:12
相关论文
共 59 条
[1]  
Armstrong EJ, 2013, J AM HEART ASSOC, V2
[2]   Genetic analysis of PSORS1 distinguishes guttate psoriasis and palmoplantar pustulosis [J].
Asumalahti, K ;
Ameen, M ;
Suomela, S ;
Hagforsen, E ;
Michaëlsson, G ;
Evans, J ;
Munro, M ;
Veal, C ;
Allen, M ;
Leman, J ;
Burden, AD ;
Kirby, B ;
Connolly, M ;
Griffiths, CEM ;
Trembath, RC ;
Kere, J ;
Saarialho-Kere, U ;
Barker, JNWN .
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2003, 120 (04) :627-632
[3]   Effect of weather and environmental factors on the clinical course of psoriasis [J].
Balato, Nicola ;
Di Costanzo, Luisa ;
Patruno, Cataldo ;
Patri, Angela ;
Ayala, Fabio .
OCCUPATIONAL AND ENVIRONMENTAL MEDICINE, 2013, 70 (08) :600-600
[4]   The role of drugs in the induction and/or exacerbation of psoriasis [J].
Basavaraj, Kabbur Hanumanthappa ;
Ashok, Navya Mysore ;
Rashmi, Ramesh ;
Praveen, Thaggikuppe Krishnamurthy .
INTERNATIONAL JOURNAL OF DERMATOLOGY, 2010, 49 (12) :1351-1361
[5]   Psoriasis patients show signs of insulin resistance [J].
Boehncke, S. ;
Thaci, D. ;
Beschmann, H. ;
Ludwig, R. J. ;
Ackermann, H. ;
Badenhoop, K. ;
Boehncke, W-H. .
BRITISH JOURNAL OF DERMATOLOGY, 2007, 157 (06) :1249-1251
[6]   Effective continuous systemic therapy of severe plaque-type psoriasis is accompanied by amelioration of biomarkers of cardiovascular risk: results of a prospective longitudinal observational study [J].
Boehncke, S. ;
Salgo, R. ;
Garbaraviciene, J. ;
Beschmann, H. ;
Hardt, K. ;
Diehl, S. ;
Fichtlscherer, S. ;
Thaci, D. ;
Boehncke, W. -H. .
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY, 2011, 25 (10) :1187-1193
[7]   Managing comorbid disease in patients with psoriasis [J].
Boehncke, Wolf-Henning ;
Boehncke, Sandra ;
Schoen, Michael P. .
BMJ-BRITISH MEDICAL JOURNAL, 2010, 340 :200
[8]   Innate immunity and antimicrobial defense systems in psoriasis [J].
Buchau, Amanda S. ;
Gallo, Richard L. .
CLINICS IN DERMATOLOGY, 2007, 25 (06) :616-624
[9]   Sequence variants in the genes for the interleukin-23 receptor (IL23R) and its ligand (IL12B) confer protection against psoriasis [J].
Capon, Francesca ;
Di Meglio, Paola ;
Szaub, Joanna ;
Prescott, Natalie J. ;
Dunster, Christina ;
Baumber, Laura ;
Gutin, Alexander ;
Abkevic, Victor ;
Burden, A. David ;
Lanchbury, Jerry ;
Barker, Jonathan N. ;
Trembath, Richard C. ;
Nestle, Frank O. .
HUMAN GENETICS, 2007, 122 (02) :201-206
[10]   Psoriasis and Other Complex Trait Dermatoses: From Loci to Functional Pathways [J].
Capon, Francesca ;
Burden, A. David ;
Trembath, Richard C. ;
Barker, Jonathan N. .
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2012, 132 (03) :915-922