Review of the Effectiveness of Transcranial Magnetic Stimulation for Post-traumatic Stress Disorder

Background: Post-traumatic stress disorder (PTSD) is a psychiatric condition with significant morbidity and limited treatment options. Transcranial magnetic stimulation (TMS) has been shown to be an effective treatment for mental illnesses including major depressive disorder. Objective: Review effectiveness of TMS for PTSD. Methods: Literature review with descriptions of primary studies as well as meta-analysis of studies with a control group. Results: Eight primary studies were identified and three studies met criteria for meta-analysis. All studies suggest effectiveness of TMS for PTSD. Additionally, right-sided may be more effective than left-sided treatment, there is no clear advantage in high versus low frequency, and the treatment is generally well tolerated. Meta-analysis shows significant effect size on PTSD symptoms that may be correlated with total number of stimulations. Conclusions: TMS for PTSD appears to be an effective and well-tolerated treatment that warrants additional study to further define treatment parameters, course, and side effects. (C) 2014 Elsevier Inc. All rights reserved.