Intracerebral delivery of a third generation EGFRvIII-specific chimeric antigen receptor is efficacious against human glioma

被引：93

作者：

Choi, Bryan D. ^{[1
,2
]}

Suryadevara, Carter M. ^{[1
]}

Gedeon, Patrick C. ^{[3
]}

Herndon, James E., II ^{[4
]}

Sanchez-Perez, Luis ^{[1
]}

Bigner, Darell D. ^{[2
,5
]}

Sampson, John H. ^{[1
,2
,5
]}

机构：

[1] Duke Univ, Med Ctr, Dept Surg, Duke Brain Tumor Immunotherapy Program,Div Neuros, Durham, NC 27710 USA

[2] Duke Univ, Med Ctr, Dept Pathol, Durham, NC 27710 USA

[3] Duke Univ, Dept Biomed Engn, Durham, NC 27710 USA

[4] Duke Univ, Dept Biostat & Bioinformat, Durham, NC 27710 USA

[5] Duke Univ, Med Ctr, Preston Robert Tisch Brain Tumor Ctr, Durham, NC 27710 USA

来源：

JOURNAL OF CLINICAL NEUROSCIENCE | 2014年 / 21卷 / 01期

基金：

美国国家卫生研究院;

关键词：

Central nervous system neoplasms; Epidermal growth factor receptor; Glioblastoma; Immunotherapy; T-lymphocytes; GROWTH-FACTOR RECEPTOR; T-CELLS; ADVERSE EVENT; SURVIVAL; THERAPY;

D O I：

10.1016/j.jocn.2013.03.012

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Chimeric antigen receptors (CAR)-transduced T cells hold great promise in the treatment of malignant disease. Here, we demonstrate that intracerebral injection with a human, epidermal growth factor receptor variant III (EGFRvIII)-specific, third generation CAR successfully treats glioma in mice. Importantly, these results endorse clinical translation of this CAR in patients with EGFRvIII-expressing brain tumors. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：189 / 190

页数：2

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