The SARS-CoV-2 spike protein: balancing stability and infectivity

被引：66

作者：

Berger, Imre ^{[1
,2
,3
,4
]}

Schaffitzel, Christiane ^{[1
,2
]}

机构：

[1] Univ Bristol, Sch Biochem, 1 Tankards Close, Bristol BS8 1TD, Avon, England

[2] Bristol Synthet Biol Ctr BrisSynBio, 24 Tyndall Ave, Bristol BS8 1TQ, Avon, England

[3] Max Planck Bristol Ctr Minimal Biol, Bristol BS8 1TS, Avon, England

[4] Univ Bristol, Sch Chem, Bristol BS8 1TS, Avon, England

来源：

CELL RESEARCH | 2020年 / 30卷 / 12期

基金：

英国工程与自然科学研究理事会; 英国生物技术与生命科学研究理事会;

关键词：

D O I：

10.1038/s41422-020-00430-4

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

引用

页码：1059 / 1060

页数：2

共 10 条

[1] Receptor binding and priming of the spike protein of SARS-CoV-2 for membrane fusion [J].

Benton, Donald J. ;

Wrobel, Antoni G. ;

Xu, Pengqi ;

Roustan, Chloe ;

Martin, Stephen R. ;

Rosenthal, Peter B. ;

Skehel, John J. ;

Gamblin, Steven J. .

NATURE, 2020, 588 (7837) :327-330

[2]

Cai YF, 2020, SCIENCE, V369, P1586, DOI [10.1126/science.abd4251, 10.1101/2020.05.16.099317]

[3]

Henderson R, 2020, NAT STRUCT MOL BIOL, V27, P925, DOI [10.1038/s41594-020-0479-4, 10.1101/2020.05.18.102087]

[4] Potent neutralizing antibodies against multiple epitopes on SARS-CoV-2 spike [J].

Liu, Lihong ;

Wang, Pengfei ;

Nair, Manoj S. ;

Yu, Jian ;

Rapp, Micah ;

Wang, Qian ;

Luo, Yang ;

Chan, Jasper F-W ;

Sahi, Vincent ;

Figueroa, Amir ;

Guo, Xinzheng, V ;

Cerutti, Gabriele ;

Bimela, Jude ;

Gorman, Jason ;

Zhou, Tongqing ;

Chen, Zhiwei ;

Yuen, Kwok-Yung ;

Kwong, Peter D. ;

Sodroski, Joseph G. ;

Yin, Michael T. ;

Sheng, Zizhang ;

Huang, Yaoxing ;

Shapiro, Lawrence ;

Ho, David D. .

NATURE, 2020, 584 (7821) :450-+

[5] Free fatty acid binding pocket in the locked structure of SARS-CoV-2 spike protein [J].

Toelzer, Christine ;

Gupta, Kapil ;

Yadav, Sathish K. N. ;

Borucu, Ufuk ;

Davidson, Andrew D. ;

Williamson, Maia Kavanagh ;

Shoemark, Deborah K. ;

Garzoni, Frederic ;

Staufer, Oskar ;

Milligan, Rachel ;

Capin, Julien ;

Mulholland, Adrian J. ;

Spatz, Joachim ;

Fitzgerald, Daniel ;

Berger, Imre ;

Schaffitzel, Christiane .

SCIENCE, 2020, 370 (6517) :725-+

[6]

Walls AC, 2020, CELL, V181, P281, DOI [10.1016/j.cell.2020.02.058, 10.1016/j.cell.2020.11.032]

[7]

Wrapp D, 2020, SCIENCE, V367, P1260, DOI [10.1126/science.abb2507, 10.1101/2020.02.11.944462]

[8] SARS-CoV-2 and bat RaTG13 spike glycoprotein structures inform on virus evolution and furin-cleavage effects [J].

Wrobel, Antoni G. ;

Benton, Donald J. ;

Xu, Pengqi ;

Roustan, Chloe ;

Martin, Stephen R. ;

Rosenthal, Peter B. ;

Skehel, John J. ;

Gamblin, Steven J. .

NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2020, 27 (08) :763-+

[9] Molecular Architecture of the SARS-CoV-2 Virus [J].

Yao, Hangping ;

Song, Yutong ;

Chen, Yong ;

Wu, Nanping ;

Xu, Jialu ;

Sun, Chujie ;

Zhang, Jiaxing ;

Weng, Tianhao ;

Zhang, Zheyuan ;

Wu, Zhigang ;

Cheng, Linfang ;

Shi, Danrong ;

Lu, Xiangyun ;

Lei, Jianlin ;

Crispin, Max ;

Shi, Yigong ;

Li, Lanjuan ;

Li, Sai .

CELL, 2020, 183 (03) :730-+

[10]

Yurkovetskiy Leonid, 2020, bioRxiv, DOI [10.1016/j.cell.2020.09.032, 10.1101/2020.07.04.187757]

← 1 →