Synthesis of 4′-(2-ferrocenyl)-2,2′:6′2"-terpyridine: Characterization and antiprotozoal activity of Mn(II), Co(II), Ni(II), Cu(II) and Zn(II) complexes

被引：31

作者：

Juneja, Annu ^{[1
]}

Macedo, Tais Soares ^{[2
]}

Magalhaes Moreira, Diogo Rodrigo ^{[2
,3
]}

Pereira Soares, Milena Botelho ^{[2
,3
]}

Lima Leite, Ana Cristina ^{[4
]}

de Andrade Lemoine Neves, Juliana Kelle ^{[5
]}

Alves Pereira, Valeria Rego ^{[5
]}

Avecilla, Fernando ^{[6
]}

Azam, Amir ^{[1
]}

机构：

[1] Jamia Millia Islamia, Dept Chem, New Delhi 110025, India

[2] Fundacao Oswaldo Cruz, Ctr Pesquisas Goncalo Moniz, BR-40296710 Salvador, BA, Brazil

[3] Hosp Sao Rafael, Ctr Biotecnol & Terapia Celular, BR-41253190 Salvador, BA, Brazil

[4] Univ Fed Pernambuco, Ctr Hlth Sci, Dept Pharmaceut Sci, BR-50740520 Recife, PE, Brazil

[5] Fundacao Oswaldo Cruz, Dept Imunol, Ctr Pesquisas Aggeu Magalhaes, BR-50670420 Recife, PE, Brazil

[6] Univ A Coruna, Dept Quim Fundamental, La Coruna 15071, Spain

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2014年 / 75卷

关键词：

Metal complexes; Terpyridine; Ferrocenyl; Amoebiasis; Malaria; ANTIAMEBIC ACTIVITY; ENTAMOEBA-HISTOLYTICA; TRYPANOSOMA-CRUZI; RUTHENIUM(II); CYTOTOXICITY; 2,2'/6',2''-TERPYRIDINE; FERROQUINE; CHEMISTRY; ENERGY;

D O I：

10.1016/j.ejmech.2014.01.051

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A terpyridine ligand Fctpy was reacted with divalent metals (Cu, Co, Mn, Ni and Zn), yielding five complexes of general formula [Metal(Fctpy)(2)][PF6](2). The structure of Fctpy was determined by single crystal X-ray diffraction studies. The complexes characterized using various spectroscopic techniques suggested an octahedral geometry around the central metal ion. These complexes were screened for their antiamoebic, trypanocidal and antimalarial activities. It was found that, complexes 2 and 3 showed better IC50 values than metronidazole against HM1:IMSS strain of Entamoeba histolytica. A substantial parasitic inhibition was not observed for the trypanocidal activity. However, for the erythrocytic stage of W2 strain of Plasmodium falciparum, the complexes inhibited beta-hematin formation. At the concentration of 10 mu g/mL, these complexes did not display toxicity. (C) 2014 Elsevier Masson SAS. All rights reserved.

引用

页码：203 / 210

页数：8

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