Identification of sequence polymorphisms in the D-loop region of mitochondrial DNA as a risk factor for non-Hodgkin lymphoma

被引：7

作者：

Gao, Yuhuan ^{[1
]}

Zhao, Guimin ^{[1
]}

Diao, Lanping ^{[1
]}

Guo, Zhanjun ^{[2
]}

机构：

[1] Hebei Med Univ, Hosp 4, Dept Hematol, Shijiazhuang 050011, Peoples R China

[2] Hebei Med Univ, Hosp 4, Dept Gastroenterol & Hepatol, Shijiazhuang 050011, Peoples R China

来源：

MITOCHONDRIAL DNA | 2014年 / 25卷 / 03期

关键词：

D-loop; mtDNA; NHL; SNP; HEPATOCELLULAR-CARCINOMA; GENETIC POLYMORPHISMS; DISPLACEMENT LOOP; PANCREATIC-CANCER; POOLED ANALYSIS; LUNG-CANCER; MUTATIONS; TRANSCRIPTION; PATHWAY; TISSUE;

D O I：

10.3109/19401736.2013.796457

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Accumulation of single nucleotide polymorphisms (SNPs) in the displacement loop (D-loop) of mitochondrial DNA (mtDNA) may be associated with an increased cancer risk. We investigated the non-Hodgkin lymphoma (NHL) risk profile of D-loop SNPs in a case-control study. The minor alleles of nucleotides 73A/G, 263A/G, 315C/C insert were associated with a decreased risk for NHL. The minor alleles of the nucleotides 200G/A were specifically associated with the risk of diffuse large B-cell lymphoma, whereas the minor allele of nucleotides 16362C/T and 249Del/A was specifically associated with the decreased risk of T-cell lymphoma. In conclusion, SNPs in mtDNA are potential modifiers of NHL risk. The analysis of genetic polymorphisms in the mitochondrial D-loop can help identify subgroups of patients who are at a high risk of developing NHL.

引用

页码：220 / 222

页数：3

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