Core-Shell Nanostars for Multimodal Therapy and Imaging

被引：33

作者：

Li, Mengyuan

Li, Lele

Zhan, Changyou

Kohane, Daniel S. ^{[1
]}

机构：

[1] Harvard Med Sch, Childrens Hosp Boston, Lab Biomat & Drug Delivery, Dept Anesthesiol,Div Crit Care Med, Boston, MA 02115 USA

来源：

THERANOSTICS | 2016年 / 6卷 / 13期

关键词：

gold nanostar; imaging; IN-VIVO; PHOTOTHERMAL THERAPY; 2-PHOTON MICROSCOPY; GOLD NANOPARTICLES; MOLECULAR PROBES; DRUG-DELIVERY; SOLID TUMORS; NANOMATERIALS; GEMCITABINE; NANOCAGES;

D O I：

10.7150/thno.15843

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The coupling of diagnostic capability and effective therapy in a single multifunctional nanomedicine is desirable but remains challenging. Here, we developed multifunctional nanoparticles consisting of a gold nanostar (AuNS) core with a shell of metal-drug coordination polymer (CP). The AuNS core enabled plasmonic photothermal effect and two-photon photoluminescence (TPL), while the CP shell of gadolinium and gemcitabine monophosphate allowed chemotherapy and MRI imaging. The AuNS@CP nanoparticles exhibited a strong T-1 contrast signal and could monitor the localization of nanoparticles in vivo through noninvasive MR imaging, while intravital TPL imaging could be used to study nanoparticle behavior in tumors at the microscopic level. The combination of photothermal therapy and chemotherapy inhibited tumor growth in vivo.

引用

页码：2306 / 2313

页数：8

共 44 条

[21] Bismuth Sulfide Nanorods as a Precision Nanomedicine for in Vivo Multimodal Imaging-Guided Photothermal Therapy of Tumor [J].

Liu, Jing ;

Zheng, Xiaopeng ;

Yan, Liang ;

Zhou, Liangjun ;

Tian, Gan ;

Yin, Wenyan ;

Wang, Liming ;

Liu, Ying ;

Hu, Zhongbo ;

Gu, Zhanjun ;

Chen, Chunying ;

Zhao, Yuliang .

ACS NANO, 2015, 9 (01) :696-707

[22] The EPR effect for macromolecular drug delivery to solid tumors: Improvement of tumor uptake, lowering of systemic toxicity, and distinct tumor imaging in vivo [J].

Maeda, Hiroshi ;

Nakamura, Hideaki ;

Fang, Jun .

ADVANCED DRUG DELIVERY REVIEWS, 2013, 65 (01) :71-79

[23] Chemically tailorable colloidal particles from infinite coordination polymers [J].

Oh, M ;

Mirkin, CA .

NATURE, 2005, 438 (7068) :651-654

[24] PEGylated liposomal Gemcitabine: insights into a potential breast cancer therapeutic [J].

Papa, Anne-Laure ;

Sidiqui, Almas ;

Balasubramanian, Sri Uma Aisvarya ;

Sarangi, Sasmit ;

Luchette, Matthew ;

Sengupta, Shiladitya ;

Harfouche, Rania .

CELLULAR ONCOLOGY, 2013, 36 (06) :449-457

[25] Targeted delivery of gemcitabine to pancreatic adenocarcinoma using cetuximab as a targeting agent [J].

Patra, Chitta Ranjan ;

Bhattacharya, Resharn ;

Wang, Enfeng ;

Katarya, Aaron ;

Lau, Julie S. ;

Dutta, Shamit ;

Muders, Michael ;

Wang, Shanfeng ;

Buhrow, Sarah A. ;

Safgren, Stephanie L. ;

Yaszemski, Michael J. ;

Reid, Joel M. ;

Ames, Matthew M. ;

Mukherjee, Priyabrata ;

Mukbopadhyay, Debabrata .

CANCER RESEARCH, 2008, 68 (06) :1970-1978

[26] Challenges and Key Considerations of the Enhanced Permeability and Retention Effect for Nanomedicine Drug Delivery in Oncology [J].

Prabhakar, Uma ;

Maeda, Hiroshi ;

Jain, Rakesh K. ;

Sevick-Muraca, Eva M. ;

Zamboni, William ;

Farokhzad, Omid C. ;

Barry, Simon T. ;

Gabizon, Alberto ;

Grodzinski, Piotr ;

Blakey, David C. .

CANCER RESEARCH, 2013, 73 (08) :2412-2417

[27] Amplifying the Red-Emission of Upconverting Nanoparticles for Biocompatible Clinically Used Prodrug-Induced Photodynamic Therapy [J].

Punjabi, Amol ;

Wu, Xiang ;

Tokatli-Apollon, Amira ;

El-Rifai, Mahmoud ;

Lee, Hyungseok ;

Zhang, Yuanwei ;

Wang, Chao ;

Liu, Zhuang ;

Chan, Emory M. ;

Duan, Chunying ;

Han, Gang .

ACS NANO, 2014, 8 (10) :10621-10630

[28] A Cell-Targeted, Size-Photocontrollable, Nuclear-Uptake Nanodrug Delivery System for Drug-Resistant Cancer Therapy [J].

Qiu, Liping ;

Chen, Tao ;

Oecsoy, Ismail ;

Yasun, Emir ;

Wu, Cuichen ;

Zhu, Guizhi ;

You, Mingxu ;

Han, Da ;

Jiang, Jianhui ;

Yu, Ruqin ;

Tan, Weihong .

NANO LETTERS, 2015, 15 (01) :457-463

[29] DNA-Encoded Tuning of Geometric and Plasmonic Properties of Nanoparticles Growing from Gold Nanorod Seeds [J].

Song, Tingjie ;

Tang, Longhua ;

Tan, Li Huey ;

Wang, Xiaojing ;

Satyavolu, Nitya Sai Reddy ;

Xing, Hang ;

Wang, Zidong ;

Li, Jinghong ;

Liang, Haojun ;

Lu, Yi .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2015, 54 (28) :8114-8118

[30] Infinite coordination polymer nano- and microparticle structures [J].

Spokoyny, Alexander M. ;

Kim, Dongwoo ;

Sumrein, Abdelqader ;

Mirkin, Chad A. .

CHEMICAL SOCIETY REVIEWS, 2009, 38 (05) :1218-1227

← 1 2 3 4 5 →