Fluometuron adsorption and dissipation under field and laboratory conditions, and distribution within the soil profile was determined in 3 soils from Tennessee, Mississippi, and Georgia that are representative of the cotton-growing regions of the southeastern United States. Fluometuron adsorption was correlated with organic matter, but not with clay content or soil pH. First-order kinetics explained fluometuron dissipation under field and controlled conditions (r(2) greater than or equal to 0.82). Field dissipation of fluometuron was slower under dry conditions. Fluometuron was not detected below 15 cm in the soil profile in any soil, and concentrations in the 8- to 15-cm soil zone were < 15 ppbw 112 d after treatment. Fluometuron dissipation was more rapid in soil from the 0- to 8-cm depth in Tennessee soil than in Mississippi soil under controlled conditions. Dissipation was more rapid under field conditions than under laboratory conditions at 2 of 3 locations. Fluometuron half-lives in soils from the 0- to 8-cm depth ranged from 9 to 28 d under field conditions and from 11 to 43 d in the laboratory. Fluometuron dissipation in soils from 30- to 45- and 60- to 90-cm depths was not different among soils, with half-lives ranging from 58 to 99 d under laboratory conditions. Fluometuron half-life was positively correlated with soil depth and inversely correlated with organic matter. These data indicate that organic matter, soil depth, and environmental conditions affect fluometuron dissipation.