A standardized core set for systemic sclerosis clinical trials. First step in development of combined response index

被引：6
作者：
Khanna, D. [1 ]
机构：
[1] Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Div Rheumatol, Los Angeles, CA 90095 USA
来源：
RHEUMATOLOGY | 2008年 / 47卷
关键词：
Provisional core set; Systemic sclerosis; Scleroderma; Response measure; Clinical trials; Combined Response Index;
D O I：
10.1093/rheumatology/ken266
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
SSc can be associated with a high morbidity and mortality. Due to the complexity and heterogeneity of the disease, a composite response measure that will capture differing organ involvements and patient-reported outcomes is desirable. Recently, with participation of the Scleroderma Clinical Trial Consortium, a standardized core set of items were proposed for SSc clinical trials using a structured Delphi exercise. The Delphi exercise identified 11 domains relevant to SSc clinical trials. Currently, efforts are under way to develop a combined response index for clinical trials in diffuse cutaneous SSc.
引用
收藏
页码：V31 / V32
页数：2
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