Boric acid and boronic acids inhibition of pigeonpea urease

被引：22
作者：
Reddy, K. Ravi Charan [1 ]
Kayastha, Arvind M. [1 ]
机构：
[1] Banaras Hindu Univ, Fac Sci, Sch Biotechnol, Varanasi 221005, Uttar Pradesh, India
来源：
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY | 2006年 / 21卷 / 04期
关键词：
urease; pigeonpea urease; boric acid; boronic acids; inhibition;
D O I：
10.1080/14756360600638147
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Urease from the seeds of pigeonpea was competitively inhibited by boric acid, butylboronic acid, phenylboronic acid, and 4-bromophenylboronic acid; 4-bromophenylboronic acid being the strongest inhibitor, followed by boric acid. butylboronic acid. phenylboronic acid, respectively. Urease inhibition by boric acid is maximal at acidic pH (5.0) and minimal at alkaline pH (10.0), i.e., the trigonal planar B(OH)(3) form is a more effective inhibitor than the tetrahedral B(OH)(4)(-) anionic form. Similarly, the anionic form of phenylboronic acid was least inhibiting in nature.
引用
收藏
页码：467 / 470
页数：4
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