Alkaloids of Aconitum coreanum.: X.: Curare-like activity-structure relationship

被引：10

作者：

Dzhakhangirov, FN ^{[1
]}

Bessonova, IA ^{[1
]}

机构：

[1] Acad Sci Republ Uzbekistan, Inst Chem Plant Subst, Tashkent, Uzbekistan

来源：

CHEMISTRY OF NATURAL COMPOUNDS | 2002年 / 38卷 / 01期

关键词：

Aconitum coreanum; Ranunculaceae; diterpenoid alkaloids; toxicity; curare-like activity;

D O I：

10.1023/A:1015742001422

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The biological activity of 11 alkaloids isolated from Aconitum coreanum was studied. The compounds exhibit myorelaxant activity. Isoatisine and coryphine, which contain oxazolidine rings, are the most active. N-Oxides of 2-isobutyryl-14-hydroxyhetisine and 2-isobutyryl-13-acetyl-14-hydroxyhetisine are least active.

引用

页码：74 / 77

页数：4

共 21 条

[1]

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[2]

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[3]

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[4]

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[5]

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[6]

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[7]

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[8]

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[9]

Dzhakhangirov FN, 1995, KHIM PRIR SOEDIN+, P841

[10]

DZHAKHANGIROV FN, 1996, KHIM PRIR SOEDIN, P384

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