Organophotoredox-Catalyzed C-H Alkylation of Imidazoheterocycles with Malonates: Total Synthesis of Zolpidem

被引：6

作者：

Chaubey, Narendra R. ^{[1
]}

Kapdi, Anant R. ^{[1
]}

Maity, Biswanath ^{[2
]}

机构：

[1] Inst Chem Technol, Dept Chem, Nathalal Parekh Rd, Mumbai 400019, Maharashtra, India

[2] Ctr Biomed Res, Translat Cell Biol Unit, Raibareli Rd, Lucknow 226014, Uttar Pradesh, India

来源：

SYNTHESIS-STUTTGART | 2021年 / 53卷 / 08期

关键词：

organophotoredox; C-H functionalization; imidazoheterocycles; zolpidem; drug prejudice; VISIBLE-LIGHT; ANTITUMOR EVALUATION; ANTIVIRAL ACTIVITY; FUNCTIONALIZATION; IMIDAZOPYRIDINES; DERIVATIVES; BOND; DNA;

D O I：

10.1055/s-0040-1706103

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Organophotocatalytic C-H bond functionalization has attracted a lot of attention in the past several years due to the possibility of catalyzing reactions in a metal- and peroxide-free environment. Continuing on these lines, an organophotoredox-catalyzed C-H functionalization of imidazo[1,2-a]pyridines and related heterocycles with bromomalonates under mild conditions is reported, providing excellent yields of the products at room temperature. This is the first report involving malonates as coupling partners leading to the synthesis of a range of functionalized products including total synthesis of zolpidem, a sedative-hypnotic drug molecule.

引用

页码：1524 / 1530

页数：7

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