Blood biomarkers for Alzheimer's disease and related disorders

被引：23

作者：

Zetterberg, Henrik ^{[1
,2
,3
,4
,5
]}

Schott, Jonathan M. ^{[4
,6
]}

机构：

[1] Univ Gothenburg, Dept Psychiat & Neurochem, Inst Neurosci & Physiol, Sahlgrenska Acad, Molndal, Sweden

[2] Sahlgrens Univ Hosp, Clin Neurochem Lab, S-43180 Molndal, Sweden

[3] UCL Inst Neurol, Dept Neurodegenerat Dis, Queen Sq, London, England

[4] UK Dementia Res Inst UCL, London, England

[5] Hong Kong Ctr Neurodegenerat Dis, Hong Kong, Peoples R China

[6] UCL, UCL Queen Sq Inst Neurol, Dementia Res Ctr, London, England

来源：

ACTA NEUROLOGICA SCANDINAVICA | 2022年 / 146卷 / 01期

基金：

欧洲研究理事会; 瑞典研究理事会;

关键词：

Alzheimer's disease; biomarker; blood biomarkers; dementia; neurofilament light; plasma; tau; amyloid; SERUM NEUROFILAMENT LIGHT; AMYLOID-BETA; PLASMA; PROTEIN; NEURODEGENERATION; ASSOCIATION; PERFORMANCE; P-TAU217; MARKER;

D O I：

10.1111/ane.13628

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Alzheimer's disease (AD) is a progressive neurodegenerative disease and the single commonest cause of dementia. Many other diseases can, however, cause dementia, and differential diagnosis can be challenging, especially in early disease stages. For most neurodegenerative dementias, accumulation of brain pathologies starts many years before clinical onset; the ability to detect these pathologies paves the way for targeted disease-modifying prevention trials. AD is associated with beta-amyloid and tau pathologies, which can be quantified using cerebrospinal fluid and imaging biomarkers and, more recently, using highly sensitive blood tests. While for the most part, specific biomarkers of non-AD neurodegenerative dementias are lacking, non-specific biomarkers of neurodegeneration are available. This review summarizes recent advances in the neurodegenerative dementia blood biomarker research and discusses the next steps required for clinical implementation.

引用

页码：51 / 55

页数：5

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