Primary bone lymphoma: A case report and review of the literature

被引:21
作者
Zhou, Hai-Yan [1 ]
Gao, Fang [1 ]
Bu, Bing [1 ]
Fu, Zheng [2 ]
Sun, Xu-Jie [3 ]
Huang, Cheng-Suo [1 ]
Zhou, Deng-Guang [1 ]
Zhang, Shu [1 ]
Xiao, Jun [1 ]
机构
[1] Shandong Canc Hosp & Inst, Internal Dept Oncol, Jinan 250117, Shandong, Peoples R China
[2] Shandong Canc Hosp & Inst, Positron Emiss Tomog Computed Tomog Ctr, Jinan 250117, Shandong, Peoples R China
[3] Shandong Canc Hosp & Inst, Dept Pathol, Jinan 250117, Shandong, Peoples R China
关键词
primary lymphoma of bone; diagnosis; therapy; prognosis; NON-HODGKINS-LYMPHOMA; B-CELL LYMPHOMA; EXTRANODAL LYMPHOMA; PROGNOSTIC-FACTORS; BRITISH-COLUMBIA; IMAGING FEATURES; EXPERIENCE; THERAPY; ADULTS; PET;
D O I
10.3892/ol.2014.2327
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Primary lymphoma of the bone (PLB) primarily arising from the medullary cavity is an extremely rare entity, with only retrospective studies and sporadic cases reported in the literature. The current study presents one case of PLB treated with chemotherapy and radiotherapy, and a review of the literature to elucidate the optimal treatment of PLB. A 73-year-old female presented with pain in the left hip that had persisted for two months. Plain X-ray and magnetic resonance imaging of the left hip showed lytic areas involving the left innominatum. Technetium-99m radionuclide imaging showed increased tracer uptake in the ilium, acetabulum and ischium. An F-18-fluorodeoxyglucose-positron emission tomography-computed tomography (FDG-PET-CT) scan showed high FDG uptake. A fine-needle aspiration biopsy of the lesion was performed, and histopathological and immunohistochemical examination confirmed a diagnosis of B-cell lymphoma. The patient received radiation therapy followed by six cycles of CHOP regimen (1,000 mg cyclophosphamide, 80 mg epirubicine and 2 mg vincristine on day one, and 100 mg prednisone on days one to five, every three weeks) and achieved a complete response, as confirmed by FDG-PET-CT. At present, the patient is in a good condition. This case is noteworthy, as it is a well-documented case in which the patient received successful treatment. This case demonstrates that PLB has an improved prognosis compared with primary lymphoma of other sites; however, combined therapy may further improve the patient outcome.
引用
收藏
页码:1551 / 1556
页数:6
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