High Agatston Calcium Score of Intracranial Carotid Artery A Significant Risk Factor for Cognitive Impairment

被引：12

作者：

Kao, Hung-Wen ^{[1
,2
]}

Liou, Michelle ^{[3
]}

Chung, Hsiao-Wen ^{[1
,4
]}

Liu, Hua-Shan ^{[5
,6
,7
]}

Tsai, Ping-Huei ^{[5
,6
,7
]}

Chiang, Shih-Wei ^{[1
,4
]}

Chou, Ming-Chung ^{[8
]}

Peng, Giia-Sheun ^{[9
]}

Huang, Guo-Shu ^{[1
]}

Hsu, Hsian-He ^{[1
]}

Chen, Cheng-Yu ^{[1
,5
,6
,7
]}

机构：

[1] Natl Def Med Ctr, Triserv Gen Hosp, Dept Radiol, Taipei, Taiwan

[2] Natl Yang Ming Univ, Dept Biomed Imaging & Radiol Sci, Taipei 112, Taiwan

[3] Acad Sinica, Inst Stat Sci, Taipei 11529, Taiwan

[4] Natl Taiwan Univ, Dept Elect Engn, Taipei 10764, Taiwan

[5] Taipei Med Univ Hosp, Dept Med Imaging, Taipei, Taiwan

[6] Taipei Med Univ, Imaging Res Ctr, Taipei, Taiwan

[7] Taipei Med Univ, Grad Inst Clin Med, Taipei, Taiwan

[8] Kaohsiung Med Univ, Dept Med Imaging & Radiol Sci, Kaohsiung, Taiwan

[9] Natl Def Med Ctr, Triserv Gen Hosp, Dept Neurol, Taipei, Taiwan

来源：

MEDICINE | 2015年 / 94卷 / 39期

关键词：

ATHEROSCLEROTIC CALCIFICATION; COMPUTED-TOMOGRAPHY; DEMENTIA; STROKE; MEN; ASSOCIATION;

D O I：

10.1097/MD.0000000000001546

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The effect of intracranial internal carotid artery (ICA) calcification on cognitive impairment is uncertain. Our objective was to investigate whether intracranial ICA calcification is a significant cognitive predictor for cognitive impairment. Global cognition and degrees of intracranial ICA calcification of 579 subjects were assessed with Mini-Mental State Examination (MMSE) and Agatston calcium scoring method, respectively. Other risk factors for cognitive impairment, including age, education level, hypertension, diabetes mellitus, smoking, hyperlipidemia, and body mass index, were documented and analyzed for their associations with cognitive function.In univariate analyses, older age, lower education level, hypertension, diabetes mellitus, and higher intracranial ICA Agatston scores were significantly associated with cognitive impairment. In ordinal logistic regression, only age and total intracranial ICA Agatston score were significant risk factors for cognitive impairment. After adjustment for the other documented risk factors, subjects were 7% (95% CI: 5-10; P<0.001) and 6% (95% CI: 0-13; P=0.04) more likely to have lower cognitive category with every year increment of age and every 100-point increment of the total intracranial ICA Agatston score respectively. These results suggest an important role of the intracranial ICA calcification on cognitive impairment.

引用

页数：5

共 29 条

[1] QUANTIFICATION OF CORONARY-ARTERY CALCIUM USING ULTRAFAST COMPUTED-TOMOGRAPHY [J].