Impaired development of fetal serotonergic neurons in intrauterine growth restricted baboons

被引：4

作者：

Ye, Wenrui ^{[1
]}

Xie, Lynn ^{[2
]}

Li, Cun ^{[2
]}

Nathanielsz, Peter W. ^{[2
]}

Thompson, Brent J. ^{[3
]}

机构：

[1] Univ Texas Hlth Sci Ctr San Antonio, Dept Physiol, San Antonio, TX 78229 USA

[2] Univ Texas Hlth Sci Ctr San Antonio, Dept OBGYN, Ctr Pregnancy & Newborn Res, San Antonio, TX 78229 USA

[3] Univ Texas Hlth Sci Ctr San Antonio, Dept Cellular & Struct Biol & Pharmacol, San Antonio, TX 78229 USA

来源：

JOURNAL OF MEDICAL PRIMATOLOGY | 2014年 / 43卷 / 04期

关键词：

brain development; fetus; intrauterine growth restriction; maternal nutrition; serotonin; RIGID-COMPULSIVE BEHAVIORS; DUTCH FAMINE; TRANSPORTER; SCHIZOPHRENIA; POLYMORPHISM; DISORDERS; REDUCTION;

D O I：

10.1111/jmp.12116

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

Background Famine and poor maternal nutrition have been associated with an increased risk for offspring developing psychiatric disorders later in life. Interestingly, impaired serotonergic signaling has been implicated in the etiology of multiple psychiatric conditions. Methods We studied development of the fetal serotonergic central nervous system in a baboon, non-human primate model of intrauterine growth restriction (IUGR). Results and Conclusions Fetal (90% of full-term) IUGR brains were comparable in size to controls, but have reduced expression of serotonergic proteins and mRNAs, as well as having fewer serotonergic neurons.

引用

页码：284 / 287

页数：4

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