Usage patterns of 'over-the-counter' vs. prescription-strength nonsteroidal anti-inflammatory drugs in France

被引：56

作者：

Duong, Mai ^{[1
]}

Salvo, Francesco ^{[3
,4
]}

Pariente, Antoine ^{[1
,2
,3
]}

Abouelfath, Abdelilah ^{[2
]}

Lassalle, Regis ^{[2
]}

Droz, Cecile ^{[1
,2
]}

Blin, Patrick ^{[2
]}

Moore, Nicholas ^{[1
,2
,3
]}

机构：

[1] INSERM, U657, Bordeaux, France

[2] CHU Bordeaux CIC P00005, Bordeaux, France

[3] Univ Bordeaux Segalen, F-33076 Bordeaux, France

[4] Ctr Neurolesi Bonino Pulejo, IRCCS, Messina, Italy

来源：

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY | 2014年 / 77卷 / 05期

关键词：

drug-related risks; over-the-counter nonsteroidal anti-inflammatory drugs; prescription nonsteroidal anti-inflammatory drugs; usage patterns; GASTROINTESTINAL COMPLICATIONS; MYOCARDIAL-INFARCTION; CARDIOVASCULAR EVENTS; HYPERTENSIVE PATIENTS; PATIENT INTERVIEWS; RISK; NSAIDS; IBUPROFEN; METAANALYSIS; CELECOXIB;

D O I：

10.1111/bcp.12239

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

AimsMost risks of nonsteroidal anti-inflammatory drugs (NSAIDs) are pharmacological, dose and duration dependent. Usage patterns of prescription-only (POM) or over-the-counter (OTC)' NSAIDs may influence risks, but are not commonly described. MethodsThe Echantillon Generaliste de Beneficiaires database, the permanent 1/97 representative sample from the French national healthcare insurance systems, was queried over 2009-2010 to identify usage patterns, concomitant chronic diseases and cardiovascular medication in OTC and POM NSAID users. ResultsOver 2 years, 229477 of 526108 patients had at least one NSAID dispensation; 44484 patients (19%) were dispensed only OTC NSAIDs (93% ibuprofen) and 121208 (53%) only POM NSAIDs. The OTC users were younger (39.9 vs. 47.4 years old) and more often female (57 vs. 53%); 69% of OTC users and 49% of POM users had only one dispensation. A mean of 14.6 defined daily doses (DDD) were dispensed over 2 years for OTCvs. 53 for POM; 93% OTCvs. 60% POM patients bought 30 DDD over 2 years, and 1.5 vs. 12% bought 90DDD. Chronic comorbidities were found in 19% of OTC users vs. 28% of POM users; 24 vs. 37% had at least one dispensation of a cardiovascular drug over the 2 years. ConclusionsMost of the use of NSAIDs appears to be short term, especially for OTC-type NSAIDs, such as ibuprofen. The validity of risk estimates for NSAIDs extrapolated from clinical trials or from observational studies not including OTC-type usage may need to be revised.

引用

页码：887 / 895

页数：9

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