Ovarian steroids and raloxifene prevent MPTP-induced dopamine depletion in mice

被引：115
作者：
Grandbois, M
Morissette, M
Callier, S
Di Paolo, T
机构：
[1] Univ Laval, Med Ctr, Oncol & Mol Endocrinol Res Ctr, Quebec City, PQ G1V 4G2, Canada
[2] St Antoine Hosp, INSERM, U339, F-75012 Paris, France
[3] Univ Laval, Fac Pharm, Quebec City, PQ G1K 7P4, Canada
来源：
NEUROREPORT | 2000年 / 11卷 / 02期
关键词：
dopamine; estradiol; mice; MPTP; Parkinson's disease; progesterone; raloxifene; steroids;
D O I：
10.1097/00001756-200002070-00024
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The activity of steroids was studied in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) lesioned retired breeder C57BL/6 male mice as a model of Parkinson's disease. Steroids were injected daily for 5 days before MPTP (4 injections, 15 mg/kg i.p., at 2 h intervals) and hormonal treatment continued for 5 more days. Mice that received 17 beta-estradiol or progesterone or raloxifene (a selective estrogen receptor modulator) and MPTP had striatal concentrations of dopamine (DA) and its metabolites dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) similar to those in control animals, whereas mice that received MPTP alone or with 17 alpha-estradiol (the isomer with weak estrogenic activity) had an extensive decrease of DA and its metabolites. These results suggest stereospecific prevention of MPTP-induced dopamine loss by 17 beta-estradiol, which is also observed with progesterone and raloxifene. NeuroReport 11:343-346 (C) 2000 Lippincott Williams & Wilkins.
引用
收藏
页码：343 / 346
页数：4
相关论文
共 28 条
[1]   Progesterone facilitates the acquisition of avoidance learning and protects against subcortical neuronal death following prefrontal cortex ablation in the rat [J].
Asbury, ET ;
Fritts, ME ;
Horton, JE ;
Isaac, WL .
BEHAVIOURAL BRAIN RESEARCH, 1998, 97 (1-2) :99-106
[2]   Neuroprotection against oxidative stress by estrogens: Structure-activity relationship [J].
Behl, C ;
Skutella, T ;
Lezoualch, F ;
Post, A ;
Widmann, M ;
Newton, CJ ;
Holsboer, F .
MOLECULAR PHARMACOLOGY, 1997, 51 (04) :535-541
[3]   17-BETA ESTRADIOL PROTECTS NEURONS FROM OXIDATIVE STRESS-INDUCED CELL-DEATH IN-VITRO [J].
BEHL, C ;
WIDMANN, M ;
TRAPP, T ;
HOLSBOER, F .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1995, 216 (02) :473-482
[4]   TROPHIC EFFECTS OF ESTRADIOL ON FETAL-RAT HYPOTHALAMIC NEURONS [J].
CHOWEN, JA ;
TORRESALEMAN, I ;
GARCIASEGURA, LM .
NEUROENDOCRINOLOGY, 1992, 56 (06) :895-901
[5]   Effects of raloxifene on bone mineral density, serum cholesterol concentrations, and uterine endometrium in postmenopausal women [J].
Delmas, PD ;
Bjarnason, NH ;
Mitlak, BH ;
Ravoux, AC ;
Shah, AS ;
Huster, WJ ;
Draper, M ;
Christiansen, C .
NEW ENGLAND JOURNAL OF MEDICINE, 1997, 337 (23) :1641-1647
[6]  
Di Paolo T, 1994, Rev Neurosci, V5, P27
[7]   17-BETA-ESTRADIOL AT A PHYSIOLOGICAL DOSE ACUTELY INCREASES DOPAMINE TURNOVER IN RAT-BRAIN [J].
DIPAOLO, T ;
ROUILLARD, C ;
BEDARD, P .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1985, 117 (02) :197-203
[8]   Estrogen as a neuroprotectant against MPTP-induced neurotoxicity in C57/B1 mice [J].
Dluzen, DE ;
McDermott, JL ;
Liu, BJ .
NEUROTOXICOLOGY AND TERATOLOGY, 1996, 18 (05) :603-606
[9]  
Franklin K B J, 2008, MOUSE BRAIN STEREOTA
[10]   Estradiol upregulates Bcl-2 expression in adult brain neurons [J].
Garcia-Segura, LM ;
Cardona-Gomez, P ;
Naftolin, F ;
Chowen, JA .
NEUROREPORT, 1998, 9 (04) :593-597
123