Regulators of PP2C Phosphatase Activity Function as Abscisic Acid Sensors

被引：1955
作者：
Ma, Yue [1 ]
Szostkiewicz, Izabela [1 ]
Korte, Arthur [1 ]
Moes, Daniele [1 ]
Yang, Yi [1 ]
Christmann, Alexander [1 ]
Grill, Erwin [1 ]
机构：
[1] Tech Univ Munich, Lehrstuhl Bot, D-85354 Freising Weihenstephan, Germany
来源：
SCIENCE | 2009年 / 324卷 / 5930期
关键词：
EARLY SEEDLING DEVELOPMENT; CRYSTAL-STRUCTURE; ABA CONTROL; ARABIDOPSIS; PROTEIN; ABI1; GERMINATION; RECEPTOR; SIGNAL; TRANSDUCTION;
D O I：
10.1126/science.1172408
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The plant hormone abscisic acid (ABA) acts as a developmental signal and as an integrator of environmental cues such as drought and cold. Key players in ABA signal transduction include the type 2C protein phosphatases (PP2Cs) ABI1 and ABI2, which act by negatively regulating ABA responses. In this study, we identify interactors of ABI1 and ABI2, which we have named regulatory components of ABA receptor (RCARs). In Arabidopsis, RCARs belong to a family with 14 members that share structural similarity with class 10 pathogen-related proteins. RCAR1 was shown to bind ABA, to mediate ABA-dependent inactivation of ABI1 or ABI2 in vitro, and to antagonize PP2C action in planta. Other RCARs also mediated ABA-dependent regulation of ABI1 and ABI2, consistent with a combinatorial assembly of receptor complexes.
引用
收藏
页码：1064 / 1068
页数：5
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