Exosomes and Cardiac Repair After Myocardial Infarction

被引：432

作者：

Sahoo, Susmita ^{[1
]}

Losordo, Douglas W. ^{[1
,2
,3
]}

机构：

[1] Northwestern Univ, Sch Med, Feinberg Cardiovasc Res Inst, Chicago, IL 60611 USA

[2] NW Mem Hosp, Chicago, IL 60611 USA

[3] NeoStem Inc, New York, NY 10170 USA

来源：

CIRCULATION RESEARCH | 2014年 / 114卷 / 02期

关键词：

adult stem cells; exosomes; microRNAs; multivesicular bodies; myocardial infarction; progenitor cells; ENDOTHELIAL PROGENITOR CELLS; BONE-MARROW; STEM-CELLS; HEART-DISEASE; ISCHEMIC CARDIOMYOPATHY; DENDRITIC CELLS; MICRORNAS; NEOVASCULARIZATION; MICROVESICLES; REGENERATION;

D O I：

10.1161/CIRCRESAHA.114.300639

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Myocardial infarction is a leading cause of death among all cardiovascular diseases. The analysis of molecular mechanisms by which the ischemic myocardium initiates repair and remodeling indicates that secreted soluble factors are key players in communication to local and distant tissues, such as bone marrow. Recently, actively secreted membrane vesicles, including exosomes, are being recognized as new candidates with important roles in intercellular and tissue-level communication. In this review, we critically examine the emerging role of exosomes in local and distant microcommunication mechanisms after myocardial infarction. A comprehensive understanding of the role of exosomes in cardiac repair after myocardial infarction could bridge a major gap in knowledge of the repair mechanism after myocardial injury.

引用

页码：333 / 344

页数：12

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