Tumor necrosis factor α signaling in skeletal muscle:: effects of age and caloric restriction

被引:65
作者
Dirks, Amie J.
Leeuwenburgh, Christiaan
机构
[1] Univ Florida, Coll Med, Inst Aging, Dept Aging & Geriatr Res,Biochem Aging Lab, Gainesville, FL 32608 USA
[2] Wingate Univ, Sch Pharm, Wingate, NC 28174 USA
关键词
TNF-alpha; NF-kappa B; skeletal muscle; caloric restriction; apoptosis; aging;
D O I
10.1016/j.jnutbio.2005.11.002
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Past the age of 50 years, aging individuals lose muscle mass at an approximate rate of 1-2% per year. This age-related muscle atrophy, termed sarcopenia, can have significant effects on individual health and quality of life and can also impact the socioeconomic status. Sarcopenia is due to both a decrease in the number of fibers and the atrophy of the remaining fibers. The mechanisms causing loss of fibers have not been clearly defined, but may likely involve apoptosis. Elevated levels of circulating tumor necrosis factor α (TNF-α) and adaptations in TNF-α signaling in aged skeletal muscle may be contributing factors for the activation of apoptosis. These adaptations may be fiber-type specific, which could explain the selective loss of type II fibers, vs. type I fibers, in the aging process. Caloric restriction, a proven antiaging intervention, is known to attenuate the loss of muscle mass and function with age. Furthermore, caloric restriction has been shown to attenuate the age-associated adaptations in TNF-α signaling in skeletal muscle, which may be a possible mechanism by which CR prevents apoptosis and the loss of muscle fibers with age. The potential role of TNF-α in the progression of sarcopenia will be discussed, as well as the effects of life-long caloric restriction on TNF-α signaling. © 2006 Elsevier Inc. All rights reserved.
引用
收藏
页码:501 / 508
页数:8
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