Clodronate liposomes: Perspectives in research and therapeutics

被引：151

作者：

van Rooijen, N ^{[1
]}

van Kesteren-Hendrix, E ^{[1
]}

机构：

[1] Free Univ Amsterdam, Fac Med, Res Inst Immunol & Inflammat, Dept Mol Cell Biol, NL-1081 BT Amsterdam, Netherlands

来源：

JOURNAL OF LIPOSOME RESEARCH | 2002年 / 12卷 / 1-2期

关键词：

clodronate; liposomes; macrophages;

D O I：

10.1081/LPR-120004780

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Liposomes encapsulating the bisphosphonate clodronate can be used for the transient suppression of macrophage functions. Given the important role of macrophages in various disorders, the application of clodronate liposomes has been studied in several models of rheumatoid arthritis, neurological disorders such as experimental allergic encephalomyelitis and spinal cord injury, autoantibody mediated disorders such as immune thrombocytopenic purpura (ITP) and for the improvement of the efficacy of gene transfer and drug targeting.

引用

页码：81 / 94

页数：14

共 54 条

[51] Transplantation of human umbilical cord blood cells in macrophage-depleted SCID mice:: Evidence for accessory cell involvement in expansion of immature CD34+CD38- cells [J].