Clodronate liposomes: Perspectives in research and therapeutics

被引：151
作者：
van Rooijen, N [1 ]
van Kesteren-Hendrix, E [1 ]
机构：
[1] Free Univ Amsterdam, Fac Med, Res Inst Immunol & Inflammat, Dept Mol Cell Biol, NL-1081 BT Amsterdam, Netherlands
来源：
JOURNAL OF LIPOSOME RESEARCH | 2002年 / 12卷 / 1-2期
关键词：
clodronate; liposomes; macrophages;
D O I：
10.1081/LPR-120004780
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Liposomes encapsulating the bisphosphonate clodronate can be used for the transient suppression of macrophage functions. Given the important role of macrophages in various disorders, the application of clodronate liposomes has been studied in several models of rheumatoid arthritis, neurological disorders such as experimental allergic encephalomyelitis and spinal cord injury, autoantibody mediated disorders such as immune thrombocytopenic purpura (ITP) and for the improvement of the efficacy of gene transfer and drug targeting.
引用
收藏
页码：81 / 94
页数：14
相关论文
共 54 条
[1]   Treatment with liposome-encapsulated clodronate as a new strategic approach in the management of immune thrombocytopenic purpura in a mouse model [J].
Alves-Rosa, F ;
Stanganelli, C ;
Cabrera, J ;
van Rooijen, N ;
Palermo, MS ;
Isturiz, MA .
BLOOD, 2000, 96 (08) :2834-2840
[2]   Rapid recovery of platelet count following administration of liposome-encapsulated clodronate in a mouse model of immune thrombocytopenia [J].
Alves-Rosa, F ;
Stanganelli, C ;
Cabrera, J ;
Cymberknop, D ;
Rubel, C ;
Vanzulli, S ;
van Rooijen, N ;
Palermo, M ;
Isturiz, MA .
BRITISH JOURNAL OF HAEMATOLOGY, 2002, 116 (02) :357-366
[3]   A MOUSE MODEL FOR HUMAN MALARIA ERYTHROCYTIC STAGES [J].
BADELL, E ;
PASQUETTO, V ;
VANROOIJEN, N ;
DRUILHE, P .
PARASITOLOGY TODAY, 1995, 11 (06) :235-237
[4]   Human malaria in immunocompromised mice:: An in vivo model to study defense mechanisms against Plasmodium falciparum [J].
Badell, E ;
Oeuvray, C ;
Moreno, A ;
Soe, S ;
van Rooijen, N ;
Bouzidi, A ;
Druilhe, P .
JOURNAL OF EXPERIMENTAL MEDICINE, 2000, 192 (11) :1653-1659
[5]  
Barrera P, 2000, ARTHRITIS RHEUM-US, V43, P1951, DOI 10.1002/1529-0131(200009)43:9<1951::AID-ANR5>3.0.CO
[6]  
2-K
[7]   LIPOSOME-MEDIATED MACROPHAGE DEPLETION - AN EXPERIMENTAL APPROACH TO STUDY THE ROLE OF TESTICULAR MACROPHAGES IN THE RAT [J].
BERGH, A ;
DAMBER, JE ;
VANROOIJEN, N .
JOURNAL OF ENDOCRINOLOGY, 1993, 136 (03) :407-&
[8]   MACROPHAGE DEPLETION IN THE RAT AFTER INTRAPERITONEAL ADMINISTRATION OF LIPOSOME-ENCAPSULATED CLODRONATE - DEPLETION KINETICS AND ACCELERATED REPOPULATION OF PERITONEAL AND OMENTAL MACROPHAGES BY ADMINISTRATION OF FREUNDS-ADJUVANT [J].
BIEWENGA, J ;
VANDERENDE, MB ;
KRIST, LFG ;
BORST, A ;
GHUFRON, M ;
VANROOIJEN, N .
CELL AND TISSUE RESEARCH, 1995, 280 (01) :189-196
[9]   REPOPULATION OF MACROPHAGES IN POPLITEAL LYMPH-NODES OF MICE AFTER LIPOSOME-MEDIATED DEPLETION [J].
DELEMARRE, FGA ;
KORS, N ;
KRAAL, G ;
VANROOIJEN, N .
JOURNAL OF LEUKOCYTE BIOLOGY, 1990, 47 (03) :251-257
[10]  
Fleisch H., 1993, BISPHOSPHONATES BONE
123456