Preparation and characterization of fluoride calcium silicate composites with multi-biofunction for clinical application in dentistry

被引：21

作者：

Dong, Zhihong ^{[1
]}

Yang, Qing ^{[3
]}

Mei, Mingyuan ^{[4
]}

Liu, Li ^{[1
]}

Sun, Jianxun ^{[5
]}

Zhao, Li ^{[6
]}

Zhou, Changchun ^{[2
]}

机构：

[1] Chengdu Univ, Sch Mech Engn, Chengdu 610106, Sichuan, Peoples R China

[2] Sichuan Univ, Natl Engn Res Ctr Biomat, Chengdu 610064, Sichuan, Peoples R China

[3] Sichuan Univ, West China Hosp, Dept Cardiol, Chengdu 610041, Sichuan, Peoples R China

[4] Stanford Univ, Canary Ctr Early Canc Detect, Sch Med, Dept Radiol, Palo Alto, CA 94306 USA

[5] Sichuan Univ, West China Hosp Stomatol, State Key Lab Oral Dis, Chengdu 610041, Sichuan, Peoples R China

[6] Sichuan Univ, West China Sch Publ Hlth, Dept Hlth Policy & Management, Chengdu 610041, Sichuan, Peoples R China

来源：

COMPOSITES PART B-ENGINEERING | 2018年 / 143卷

关键词：

Fluoride calcium silicate; Apatite; Biological properties; Biocompatibility; PULP STEM-CELLS; DENTAL-CARIES; IN-VITRO; ENAMEL DEFECTS; REMINERALIZATION; BIOMATERIALS; PREVALENCE; INHIBITION; FLUOROSIS; BEHAVIOR;

D O I：

10.1016/j.compositesb.2018.02.009

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

Fluoride calcium silicate (FCS) are widely used in dental tissue engineering due to their excellent biological properties. This study aimed to develop novel FCS with multiple biofunctions as toothpaste additives. In this study, the preparation of composite FCS, morphologies of the composites and the in vitro biofunctions were investigated. Calcium silicate with 0.7% (wt) fluoride was prepared by co-precipitation method. Pure calcium silicate (CS) was synthesized for controlling study. Biomimetic mineralization study was conducted in simulated body fluid (SBF), the composition, phase structure, apatite formation and morphology were investigated by Xray Fluorescence Analysis (XPS), X-ray diffraction analysis (XRD), Fourier transform infrared spectroscopy (FTIR), scanning electron microscope (SEM) and transmission electron microscope (TEM). In vitro cell viability studies showed that the fluoride ions promoted cell proliferation and differentiation. This study indicated that FCS shown good bioactivity to induce apatite formation and it could be a promising toothpaste additives with specific biofunction.

引用

页码：243 / 249

页数：7

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