Formation of COPI-coated vesicles at a glance

被引：88

作者：

Arakel, Eric C. ^{[1
]}

Schwappach, Blanche ^{[1
,2
]}

机构：

[1] Univ Med Gottingen, Dept Mol Biol, Humboldtallee 23, D-37073 Gottingen, Germany

[2] Max Planck Inst Biophys Chem, D-37073 Gottingen, Germany

来源：

JOURNAL OF CELL SCIENCE | 2018年 / 131卷 / 05期

关键词：

Arf1; ArfGAP; COPI; Coatomer; Golgi; Endoplasmic reticulum; Vesicle coat; GUANINE-NUCLEOTIDE EXCHANGE; NUCLEAR-ENVELOPE BREAKDOWN; ADP-RIBOSYLATION FACTOR-1; GTPASE-ACTIVATING PROTEIN; STRUCTURE-BASED MECHANISM; KDEL RECEPTOR; CONFORMATIONAL-CHANGE; TRANSPORT VESICLES; GOLGI TRANSPORT; RETROGRADE TRANSPORT;

D O I：

10.1242/jcs.209890

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The coat protein complex I (COPI) allows the precise sorting of lipids and proteins between Golgi cisternae and retrieval from the Golgi to the ER. This essential role maintains the identity of the early secretory pathway and impinges on key cellular processes, such as protein quality control. In this Cell Science at a Glance and accompanying poster, we illustrate the different stages of COPI-coated vesicle formation and revisit decades of research in the context of recent advances in the elucidation of COPI coat structure. By calling attention to an array of questions that have remained unresolved, this review attempts to refocus the perspectives of the field.

引用

页数：9

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